酮洛芬缓释微丸的制备及体外药物释放考察  

Preparation and in vitro release of ketoprofen sustained-release pellets

作　　者：郭映君[1] 邱诗 孙辉辉[1] 孙英华[1] 何仲贵[1] 

机构地区：[1]沈阳药科大学药学院

出　　处：《中国药剂学杂志（网络版）》2009年第4期218-226,共9页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的制备酮洛芬缓释微丸并考察其体外药物释放的影响因素。方法采用粉末层积法以离心造粒技术制备载药微丸,选用丙烯酸树脂EudragitNE30D和EudragitL30D-55混合物作为包衣材料制成膜控式24h缓释微丸,以释放度测定法单因素考察影响药物释放的各种因素。结果制备的微丸圆整度好,收率达90%以上;水分散体比例、包衣增重是影响药物释放的关键因素,体外释药速率随介质pH值的增加而加快。结论酮洛芬缓释微丸体外药物释放具有明显的缓释特性,释药规律符合一级释药模型。Objective To prepare ketoprofen sustained-release pellets and study their in vitro release characteristics. Methods Pellets were prepared by centrifugal-coating granulation method,using Eudragit NE30D and EudragitL30D-55 mixture as sustained-release coating materials. Factors influencing the release rate of ketoprofen from the sustained-release pellets were studied. Results The coated pellets showed an excellent roundness and the yield was over 90%. The release rate of ketoprofen was mainly affected by the coating level and the ratio of EudragitNE30D and EudragitL30D-55,and it increased with the raise of the medium pH. Conclusions Ketoprofen sustained–release pellets were successfully prepared. The in vitro drug release profile followed first order kinetics.

关 键 词：药剂学 缓释微丸 离心造粒 酮洛芬 丙烯酸树脂(EudragitNE30D EudragitL30D-55) 

分 类 号：R943[医药卫生—药剂学]