离心造粒法制备左旋泮托拉唑钠肠溶微丸  

Preparation of (-)-pantoprazole sodium enteric-coated pellets by centrifugal granulation technology

作　　者：张春叶[1] 王东凯[1] 姚建美[1] 崔文奇[1] 张翠霞[1] 王庆河 程卯生[2] 

机构地区：[1]沈阳药科大学药学院 [2]沈阳药科大学制药工程学院

出　　处：《中国药剂学杂志（网络版）》2008年第1期14-18,共5页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的制备左旋泮托拉唑钠肠溶微丸。方法采用离心造粒法及流化床包衣法制备左旋泮托拉唑钠肠溶微丸。结果制备的左旋泮托拉唑钠肠溶微丸在pH=1.2的盐酸溶液中2h的释放度低于10%,在pH=6.8的磷酸盐缓冲液中45min的释放度大于75%。结论离心造粒法制备左旋泮托拉唑钠肠溶微丸的工艺可行、质量可靠。Objective To prepare the (-)-pantoprazole sodium enteric-coated pellets. Methods The (-)-pantoprazole sodium enteric-coated pellets were prepared by centrifugal granulation and fluid-bed coating method. Results In the first 2 h, the (-)-pantoprazole sodium enteric-coated pellets released less than 10% in pH=1.2 hydrochloric acid solution and then released more than 75% in pH=6.8 phosphoric buffer within 45 min. Conclusions The preparation of (-)-pantoprazole sodium enteric-coated pellets is feasible and the quality of the pellets is reliable.

关 键 词：药剂学 左旋泮托拉唑钠 肠溶微丸 离心造粒 流化床 

分 类 号：R94[医药卫生—药剂学]