玄丹巴布剂中淫羊藿苷透皮吸收影响因素的初步研究  

Study on percutaneous permeation for icarrin in Xuandan cataplasm

作　　者：李骄[1] 孟舒[1] 张振秋[1] 逄秀娟[1] 

机构地区：[1]沈阳药科大学药学院

出　　处：《中国药剂学杂志（网络版）》2008年第1期19-24,共6页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的对玄丹巴布剂中的主药淫羊藿透皮特性进行研究,探讨影响主要有效成分淫羊藿苷透皮吸收的主要因素。方法以淫羊藿苷为指标性成分,采用体外Franz扩散池法进行体外透皮吸收实验;采用高效液相色谱法对体外经皮渗透实验接收液中淫羊藿苷的含量进行测定。结果淫羊藿苷在不同药液(淫羊藿提取液1、淫羊藿提取液2、玄丹巴布剂药液)中具有不同的经皮渗透效果;2%(质量分数)氮酮+2%(质量分数)薄荷脑合用时促渗效果更佳;用水与生理盐水为接收液,他们的透过率相近,以磷酸水溶液为接收液透过量最少。结论淫羊藿苷体外透皮吸收良好。Objective To study percutaneous permeation for icariin of babu plaster in vitro. Methods Drug permeation experiments were performed through excised skin with Franze diffusion cells. Icarrin concentration in sample was determined by reversed-phase high performance liquid chromatography (HPLC). Results The transdermal permeation of different medicine is different. The compound penetration enhancer consisting of 1-menthol (2%) and azone (2%) had a prominent promotion action on absorption of icarrin. The water and NaCl (0.9%) solution as receiving medium effect on transdermal pernetration of icarrin is better than acid water. Conclusion The transdermal delivery of Xuandan babugao is good.

关 键 词：药剂学 巴布剂 中药 透皮吸收 体外 淫羊藿苷 Franz扩散池法 

分 类 号：R283[医药卫生—中药学]