生物可降解聚合物载药纳米粒的制备与应用  

Preparation And Application of Biodegradable Polymeric rug-loaded Nanoparticles

作　　者：尹翔[1] 王吉伟[1] 李子博[2] 

机构地区：[1]卫生部肝胆肠疾病研究中心,湖南长沙410008 [2]长沙医学院化学实验室,湖南长沙410219

出　　处：《长沙医学院学报》2007年第1期21-25,共5页Journal of Changsha Medical University

摘　　要：作为一类极富发展和应用前景的药物载体控释系统,生物可降解聚合物纳米粒不但能最终被机体分解而不会产生严重的累积和毒副效应,还具有十分明显的药物缓释效果。本文从生物可降解聚合物纳米粒的材料、制备方法,以及药物纳米控释系统在医学中的应用等几个方面,综述了生物可降解聚合物载药纳米粒的研究现状及其进展。As a controlled drug carrier delivery system with extremely good prospect,biodegradble polymeric nanoparticles could not only be decomposed by body without any harmful accumulations and side effects,but also have an obvious delayed release effect.The authors have reviewed the current research situation and progress of biodegradable polymeric drug-loaded nanoparticles from such aspects as the materials,preparation methods and the applications of nano-controlled drug deliver system in medicine.

关 键 词：生物可降解聚合物 纳米粒 载体 纳米控释系统 

分 类 号：R94[医药卫生—药剂学]