青参附液对血清肿瘤坏死因子活性的影响  

Effect of QSF on The Changes of Serum Activity of Tumour Necrosis Factor in Rabbits With Endotoxic Shock

作　　者：文海平 王海涛 赵华香[2] 贺金凯[2] 王响群[2] 李云贵[2] 

机构地区：[1]长沙市中医院,湖南长沙410002 [2]长沙医学院,湖南长沙410219

出　　处：《长沙医学院学报》2006年第2期22-27,共6页Journal of Changsha Medical University

摘　　要：目的:观察青参附液(QSF)对兔受内毒素(LPS)刺激后血清肿瘤坏死因子(TNF)活性改变的影响。方法将12只新西兰兔随机分为A、B两组,A组动物分别于大肠杆菌内毒素(LPS)注射前67小时起腹腔注射生理盐水(NS)0.2ml/kg作为空白对照,B组则按相同时间间隔腹腔注射QSF0.5mg/kg。所有动物经卡介苗(BCG)致敏后,静脉注射LPS2μg/kg诱发休克。结果预先注射QSF能显著降低动物血清TNF峰值浓度(P<0.05);治疗组平均动脉压(MAP)和全血白细胞数(WBC)下降程度也较对照组明显减轻。结论QSF对动物体内TNF的合成或分泌具有抑制作用。Objective: In order to determine the effect of solutio QSF on the changes of serum tumour necrosis factor(TNF) activity induced by lipopolysaccharide(LPS)in rabbits. Methods: Twelve New Zealand white rabbits were equally divided into group A and group B . Rabbits in group A were intravenously administered with 0.2ml/kg of normal saline(NS) from 67h before LPS injection,while those in group B were given 0.5mg/kg of QSF instead of NS at the same time course.Endotoxic shock was induced by intravevous injection of 2μg/kg of LPS after the challenge by Bacillus Calmette Guerin(BCG). Results: Preinfusion of QSF significantly decreased the peak level of serum TNF activity (P<0.05), and all decrease of mean arterial pressure (MAP)and white bood cell (WBC)count, but the decrement in group B were obviously alleviatory as compared to group A.Conclusion: QSF can inhibit the synthesis or secretion of TNF in vivo.

关 键 词：青参附液 内毒素 肿瘤坏死因子 

分 类 号：R285[医药卫生—中药学]