通脉冲剂对冠心病患者的血浆D-二聚体影响的临床观察  

Clinical Observation on Effect of Tongmaichongji on plasma D-dimeride in The Patient of Coronary Heart Disease'

作　　者：胡咏华 李云贵[2] 彭素芳[2] 刘卫平[2] 符平[2] 成正雄[2] 

机构地区：[1]长沙市第六医院,湖南长沙410002 [2]长沙医学院药理教研室

出　　处：《长沙医学院学报》2006年第2期28-32,共5页Journal of Changsha Medical University

摘　　要：目的观察中药剂型通脉冲剂治疗缺血性心脑血管疾病、动脉硬化、脑血栓、脑缺血、冠心病、心绞痛等症的疗效。方法将51例冠心病患者分为稳定型心绞痛,不稳定型心绞痛,急性心肌梗塞,正常对照组四个组并分别予口服通脉冲剂,观察4周,服药前和服药后分别空腹抽取受检者静脉血2ml,留待测D-二聚体含量。再将结果作统计学分析结果给通脉冲剂4周后:①受试者体内的D-二聚体值与给药前相比都有了显著的降低(p<0.01)。②其中急性心肌梗塞病人降低最多(p<0.01)。结论通脉冲剂对冠心病患者血浆中D-二聚体含量有降低作用,可能与通脉冲剂中的丹参、川芎嗪等有抑制凝血功能,促进纤溶系统功能,抑制血小板粘附、血小板第3因子及延长血清凝血酶原时间的作用有关。通脉冲剂对血液流变学的异常有肯定的治疗意义,而且未见任何毒副反应。Objective: To observe the curative effecs of tongmaichongji of Chinese materia medica to fred tment of the ischemic of cardiovascular disease and CHD, arterial sclerosis,cerebral thrombosis,cerebral ischemia,coronary heart disease,angina pectoris. Methods:51 patients of coronary heart disease were assigned to SA group,UA group, AMI group,normal control group and to give tongmaichongji by oral every group, to observe 4wk,hemospasia 2ml from venous before for oral use pharmaceutical product and hemospasia 2ml from venous after for oral pharmaceutical product empty stomach,to measure the contents of venous blood's D-dimeride content, to analysis results by statistics then.Results:after to give tongmaichongji 4wk :① subjects' endosomatic D-dimeride have conspicuous lower than befor for oral pharmaceutical product(p<0.01);②D-dimeride the of patients with AMI were degraded more than other group(p<0.01). Conclusions: Tongmaichongji can degrade plasma endosomatic D-dimeride, it is possible relate that dangshen, chuanxiong can inhibit platelet adhesion, PF-Ⅲ and prolong serum prothrombin time. Tongmaichongji can correct hemorheological abnormality,but not was adverse reaction.

关 键 词：通脉冲剂 心脑血管疾病 冠心病 D-二聚体 

分 类 号：R259[医药卫生—中西医结合]