78株嗜麦芽窄食单胞菌的临床分布及耐药性分析  

The clinical distribution and drug resistance analysis of 78 strains of Stenotrophomonas maltopblia

作　　者：付祖姣[1] 李敏[1] 李子博[1] 杨芳慧[1] 周江[1] 周琳[1] 张成[1] 唐荣[1] 

机构地区：[1]中南大学药学院,湖南长沙410013

出　　处：《长沙医学院学报》2013年第1期9-12,共4页Journal of Changsha Medical University

基　　金：省教育厅项目(11C0137)

摘　　要：目的了解临床分离的嗜麦芽窄食单胞茵(Stenotrophomonas maltophilia,简称SMA)的临床分布及其耐药性,为临床合理用药提供依据。方法收集2010年7月至2011年4月湖南省妇幼保健院门诊和住院患者送检标本,进行细茵培养,挑取革兰氏阴性细茵进行氧化酶试验,对氧化酶阴性细茵进行菌种鉴定和耐药性分析。结果本研究分离到78株SMA茵株,其中,痰标本的分离率最高(35.89%),其次为脓液(17.95%)、宫颈分泌物(15.38%)、创面分泌物(12.82%)、咽拭子(10.26%)、血液(3.85%)、尿液(3.85%)。药敏结果显示,SMA茵株对很多抗茵药物具有不同程度的耐药性,其耐药率分剐为:米诺环素(6.41%)、左氧氟沙星(8.97%)、复方新诺明(11.54%)、头孢他啶(24.36%)、环丙沙星(28.21%)、头孢哌酮(38.46%)、替卡西林/克拉维酸为(43.56%)、亚胺培南(100%)。结论:临床分离并鉴定的SMA茵株,以痰标本为主。这些菌株对亚胺培南具有天然耐药性,但对米诺环素、左氧氟沙星、复方新诺明的耐药率较低。建议临床在治疗SMA感染时,尽量选用SMA敏感的药物,并合理使用。Objective To provide the basis for the suitable clinic antibiotic management, the clinical distribution and drug resistance of Stenotrophomonas mahophilia(SMA) was studied. Methods Samples from outpatients and inpatlents of Maternal and Child Health Hospital of Hunan Province from July 2010 to April 2011 were collected and cultured. Then the G-strains were detected by oxidase test. The oxidase-negative strains were identitled. and the drug resistance tests of these strains were carried. Result 78 SMA strains were isolated from different samples. Among them, sputum samples has the highest isolation rate(35.89%), then fester, cervical secretion, wound secretion, throat swab, blood, urine. Drug resistance tests shows SMA strains are resistance to many anti-bacterial drugs. The levels are: minocycline(6.41%), levofloxaein(8.97%), TMP/SMZ(11.54%), ceftazidime(24.36%), eiprofloxaein(28.21%), cefoperazone(38.46%), ticarcillinclavulanate(43.56%), imipenem(100%). Conelusion SMA strains isolated from clinical samples mainly come from sputum specimens. These strains show a natural resistance to imipenem,but show low resistance to minocycline,1evofloxacin, TMP/SMZ. It suggest the doctor to try to choose SMAhighly susceptible drugs to treat the infection by SMA in clinical, and use them suitably.

关 键 词：嗜麦芽窄食单胞茵 临床分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]