吡喹酮长循环纳米粒在家兔体内的药动学  

Pharmacokinetics of Long-circulating Nanoparticles Containing Praziquantel in Rabbits

作　　者：邹永华[1] 丁劲松[1] 向大雄[2] 张龙贵[3] 马宁[2] 

机构地区：[1]中南大学药学院,湖南长沙410013 [2]中南大学湘雅二医院药学部,湖南长沙410011 [3]长沙医学院,湖南长沙410219

出　　处：《长沙医学院学报》2014年第1期26-28,36,共4页Journal of Changsha Medical University

基　　金：湖南省教育厅(09A011)重点项目

摘　　要：健康成年家兔18只,随机分为3组,分别静注吡喹酮溶液、吡喹酮纳米粒和吡喹酮长循环纳米粒(10 mg/kg)。以地西泮为内标,采用HPLC法测定家兔血浆中的吡喹酮。吡喹酮注射液和吡喹酮纳米粒的体内过程符合二房室模型,吡喹酮长循环纳米粒的体内过程符合三房室模型,3种制剂的主要药动学参数分别为:t_(1/2)(1.27±1.56)、(1.13±0.66)和(23.82±8.94)h,CL(5.29±0.78)、(2.38±1.00)和(1.16±0.16)L·h^(-1)·kg^(-1)1,AUC_(0-t)(1.48±0.27)、(3.52±1.79)和(4.93±1.27)mg·h·ml_(-1),MRT(0.44±0.30)、(0.41±0.10)和(16.12±1.38)h。Eighteen rabbits were randomly divided into three groups and intravenous administration of praziquantel solution,praziquantel nanoparticles and praziquantel long-circulating nanoparticles,respectively.The concentration of praziquantel in rabbit plasma were determined by HPLC.The pharmacokinetics of praziquantel solution and praziquantel nanoparticles was fi tted into a two-compartment open model,and praziquantel longcirculating nanoparticles was fi tted into a three-compartment open model.The main pharmacokinetic parameters were as follows:t_(1/2)(1.27±1.56),(1.13±0.66) and(23.82±8.94)h,CL(5.29±0.78),(2.38±1.00)and(1.16±0.16)L·h^(-1)·kg^(-1),AUC_(0→t)(l.48±0.27),(3.52±1.79)and(4.93±1.27)mg·h·ml^(-1),MRT(0.44±0.30),(0.41±0.10)and(16.12±1.38)h.

关 键 词：吡喹酮 长循环纳米粒 高效液相色谱 药动学 

分 类 号：R969[医药卫生—药理学]