Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in southeastern Iran  

作　　者：Ebrahim Miri-Moghaddam Zakaria Bameri Mehdi Mohamadi 

机构地区：Genetics of Non-Communicable Disease Research Centre,Zahedan University of Medical Sciences Department of Genetics,Zahedan University of Medical Sciences Infections and Tropical Research Center,Zahedan University of Medical Sciences Health Promotion Research Center,Zahedan University of Medical Sciences

出　　处：《Asian Pacific Journal of Tropical Medicine》2014年第3期202-206,共5页亚太热带医药杂志（英文版）

摘　　要： Objective:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran.Methods:In this study,the Duffy blood group FY phenolypes were determined using indireet anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control individuals.Results:The results showed that the most common Duffy geitolype was FYA/FYB(46.6%)followed by FYA/FYA(15.3%),FYA/FYO(14.4%),FYB/FYO(11.9%,),FYB/FYB(10%)and FYO/FYO(1.9%).In case individuals,frequency of FY A.FYB and FYO alleles were 0.471,0.431and 0.097,respectively compaired to 0.444,0.353 and 0.203,respectively in control(non-infected)group.Conclusions:This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.Objective:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran.Methods:In this study,the Duffy blood group FY phenolypes were determined using indireet anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control individuals.Results:The results showed that the most common Duffy geitolype was FYA/FYB(46.6%)followed by FYA/FYA(15.3%),FYA/FYO(14.4%),FYB/FYO(11.9%,),FYB/FYB(10%)and FYO/FYO(1.9%).In case individuals,frequency of FY A.FYB and FYO alleles were 0.471,0.431and 0.097,respectively compaired to 0.444,0.353 and 0.203,respectively in control(non-infected)group.Conclusions:This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.

关 键 词：MALARIA VIVAX Duffy Blood group GENOTYPE ALLELE Balouch Iran PLASMODIUM VIVAX 

分 类 号：R382[医药卫生—医学寄生虫学]