Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat  

作　　者：Hong Jiang Juan-Juan Lei Yi-He Zhang 

机构地区：[1]Neonatal Department,Affiliated Hospital of Yan'an University of Shaanxi Province

出　　处：《Asian Pacific Journal of Tropical Medicine》2014年第6期496-500,共5页亚太热带医药杂志（英文版）

基　　金：supported by Social Development Science and Technology Research Projects of Shanxi Province(2011 ks-30)

摘　　要：Objective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain injury.Methods:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group,conventional treatment group and degradation therapy group(n=90).After surgical treatment,sham and ischemic hypoxia group were treat with normal saline:conventional treatment group was received Tl'M solution 100 mg/kg.2 times/d:degradation therapy group received TPM solution 150 mg/kg.2 times/d.per 3 d treatment each dosage was reduced 50 mg/kg.the lowest reduced to 50 mg/kg.Four groups received continuous treatment for 10 d.After treatment for 1 d.4 d.7 d.10 d the cercbral edema,neuron-specific enolase(NSE)and γ-aminobutyric acid(GABA) levels and cognitive abilities of four groups were observed.Results:After 1d.4d of treatment,the brain water conlenl and NSE levels in ischemia and hypoxia group,the conventional treatment group and the degradation therapy group were significantly higher than that in sham group(P<0.05),the brain water content and NSE levels of the conventional treatment group and the degradation therapy group were significantly lower than that in the ischemic hypoxia group(P<0.05).GABA levels and learning ability of the ischemia and hypoxia group,the conventional treatment group and degradation therapy group were significantly lower than the sham group(P<0.05).the GABA levels and learning ability of the conventional treatment group and degradation therapy group were significantly higher than the ischemia and hypoxia group(P<0.05).After 7d.10 d of treatment,the brain water content and NSE levels in the sham operation group,the conventional treatment group and degradation therapy group were significantly lower than the ischemia and hypoxia group(P<0.05).while the GABA levels and learning ability of these three groups were significantly higher than that in the ischemia and hypoxia group(P<0.05>.the GABA levels in the conventional treatment group were significantly higher than degradatObjective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain injury.Methods:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group,conventional treatment group and degradation therapy group(n=90).After surgical treatment,sham and ischemic hypoxia group were treat with normal saline:conventional treatment group was received Tl’M solution 100 mg/kg.2 times/d:degradation therapy group received TPM solution 150 mg/kg.2 times/d.per 3 d treatment each dosage was reduced 50 mg/kg.the lowest reduced to 50 mg/kg.Four groups received continuous treatment for 10 d.After treatment for 1 d.4 d.7 d.10 d the cercbral edema,neuron-specific enolase(NSE)and γ-aminobutyric acid(GABA) levels and cognitive abilities of four groups were observed.Results:After 1d.4d of treatment,the brain water conlenl and NSE levels in ischemia and hypoxia group,the conventional treatment group and the degradation therapy group were significantly higher than that in sham group(P&lt;0.05),the brain water content and NSE levels of the conventional treatment group and the degradation therapy group were significantly lower than that in the ischemic hypoxia group(P&lt;0.05).GABA levels and learning ability of the ischemia and hypoxia group,the conventional treatment group and degradation therapy group were significantly lower than the sham group(P&lt;0.05).the GABA levels and learning ability of the conventional treatment group and degradation therapy group were significantly higher than the ischemia and hypoxia group(P&lt;0.05).After 7d.10 d of treatment,the brain water content and NSE levels in the sham operation group,the conventional treatment group and degradation therapy group were significantly lower than the ischemia and hypoxia group(P&lt;0.05).while the GABA levels and learning ability of these three groups were significantly higher than that in the ischemia and hypoxia group(P&lt;0.05&gt;.the GABA levels in the conventional treatment group were significant

关 键 词：TPM Brain Injury NSE GABA 

分 类 号：R722.1[医药卫生—儿科]