Prevalence of parasitemia and associated immunodeficiency among HIV—malaria co—infected adult patients with highly active antiretroviral therapy  

作　　者：Caroline Edijana Omoti Chiedozie K.Ojide Patrick V.Lofor Emeka Eze Joy C Eze 

机构地区：Department of Haematology and Blood Transfusion,University of Benin Teaching Hospital,Benin City,Nigeria Department of Medical Microbiology,University of Benin Teaching Hospital,Benin City,Nigeria Department of Internal Medicine,University of Benin Teaching Hospital,Benin City,Nigeria

出　　处：《Asian Pacific Journal of Tropical Medicine》2013年第2期148-152,共5页亚太热带医药杂志（英文版）

摘　　要：Objective:To investigate the malaria parasitemia,CD4~+ cell counts and some haematological indices among HIV-malaria co-infected adult patients with highly active antiretroviral therapy (HAART).Methods:A total of 342 adult HIV positive subjects were recruited at the consultant outpatient HIV/AIDS clinic.University of Benin Teaching Hospital,Benin City,Nigeria between June 2011 to November 2011.Blood samples were taken for malaria parasite count,CD4~+ cell count and other haematological counts.Results:Out of the 342 adult HIV positive subjects a total of 254 patients(74.3%) were found to have malaria parasitemia.The incidence of malaria parasitemia increased with advancing clinical stage of HIV infection and this was statistically significant(P=0.002).There was no statistical significance when gender was compared with the HIV-malaria status(P】0.05).Of the 254 co-infected patients,134(52.8%) had high parasitemia (】1.25×10~9/L).Sixty patients were found to be hyperparasitemic(】2.5 parasites/L).There was a significant association between CD4~+ cell count and having significant parasitemia(P【0.0001). About half(50.8%) of co-infected patients had CD4~+ cell count≤200/μL,and majority(44.9%) of this population also had significant parasitemia.Anaemia and thrombocytopenia were not significantly associated with HIV-malaria co-infection(P】0.05).Conclusions:The prevalence of parasitemia is high among the HIV/AIDS infected patients. <正>Objective:To investigate the malaria parasitemia,CD4~+ cell counts and some haematological indices among HIV-malaria co-infected adult patients with highly active antiretroviral therapy (HAART).Methods:A total of 342 adult HIV positive subjects were recruited at the consultant outpatient HIV/AIDS clinic.University of Benin Teaching Hospital,Benin City,Nigeria between June 2011 to November 2011.Blood samples were taken for malaria parasite count,CD4~+ cell count and other haematological counts.Results:Out of the 342 adult HIV positive subjects a total of 254 patients(74.3%) were found to have malaria parasitemia.The incidence of malaria parasitemia increased with advancing clinical stage of HIV infection and this was statistically significant(P=0.002).There was no statistical significance when gender was compared with the HIV-malaria status(P>0.05).Of the 254 co-infected patients,134(52.8%) had high parasitemia (>1.25×10~9/L).Sixty patients were found to be hyperparasitemic(>2.5 parasites/L).There was a significant association between CD4~+ cell count and having significant parasitemia(P<0.0001). About half(50.8%) of co-infected patients had CD4~+ cell count≤200/μL,and majority(44.9%) of this population also had significant parasitemia.Anaemia and thrombocytopenia were not significantly associated with HIV-malaria co-infection(P>0.05).Conclusions:The prevalence of parasitemia is high among the HIV/AIDS infected patients.

关 键 词：HIV MALARIA HAART CD4~+ 

分 类 号：R531.3[医药卫生—内科学]