Scrub typhus:pathophysiology,clinical manifestations and prognosis  

作　　者：Senaka Rajapakse Chaturaka Rodrigo Deepika Fernando 

机构地区：[1]Department of Clinical Medicine,Faculty of Medicine,25 Kynsey Road,Colombo 8,Sri Lanka [2]Department of Parasitology,Faculty of Medicine,25 Kynsey Road,Colombo 8,Sri Lanka

出　　处：《Asian Pacific Journal of Tropical Medicine》2012年第4期261-264,共4页亚太热带医药杂志（英文版）

摘　　要：Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi(O.tsvtsugamushi). The disease has significant prevalence in eastern and Southeast Asia.Usually presenting as an acute febrile illness,the diagnosis is often missed because of similarities with oilier tropical febrile infections.Many unusual manifestations are present,and these are described in this review,together with an outline of current knowledge of pathophysiology.Awareness of these unusual clinical manifestations will help the clinician to arrive at an early diagnosis,resulting in early administration of appropriate antibiotics.Prognostic indicators for severe disease have not yet been clearly established.Scrub typhus is a zoonosis caused by the pathogen Orientia tsutsugamushi(O.tsvtsugamushi). The disease has significant prevalence in eastern and Southeast Asia.Usually presenting as an acute febrile illness,the diagnosis is often missed because of similarities with oilier tropical febrile infections.Many unusual manifestations are present,and these are described in this review,together with an outline of current knowledge of pathophysiology.Awareness of these unusual clinical manifestations will help the clinician to arrive at an early diagnosis,resulting in early administration of appropriate antibiotics.Prognostic indicators for severe disease have not yet been clearly established.

关 键 词：SCRUB TYPHUS Orientia TSUTSUGAMUSHI Clinical MANIFESTATIONS 

分 类 号：R513.2[医药卫生—内科学]