Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds(Apocynacaea) in rats  

作　　者：Okonta Jegbefume Mathew Adibe Maxwell Ogochukwu Ubaka Chukwuemeka Michael 

机构地区：[1]Department of Clinical Pharmacy and Pharmacy Management,Faculty of Pharmaceutical Sciences,University of Nigeria,Nsukka

出　　处：《Asian Pacific Journal of Tropical Medicine》2011年第1期13-15,共3页亚太热带医药杂志（英文版）

摘　　要：Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction.They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.Results:Oral administration of the methanol extract,chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%,40.0%and 56.3%,respectively;and the fractions of the extract significantly(P【0.05) reduced gastric emptying time when compared to the control.Gastric acidity was significandy decreased when compared with saline group,40.25 mEq/ L in methanol extract,50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fration but had no significant effect on the gastric secretion volume.Conclusions:These findings showed that methanol extract,chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction.They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.Results:Oral administration of the methanol extract,chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%,40.0%and 56.3%,respectively;and the fractions of the extract significantly(P<0.05) reduced gastric emptying time when compared to the control.Gastric acidity was significandy decreased when compared with saline group,40.25 mEq/ L in methanol extract,50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fration but had no significant effect on the gastric secretion volume.Conclusions:These findings showed that methanol extract,chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.

关 键 词：Picralima nitida Aspirin-pylorus-ligation ANTIULCER RATS 

分 类 号：R285.5[医药卫生—中药学]