Antifungal activity of Ocimum sanctum Linn.(Lamiaceae) on clinically isolated dermatophytic fungi  

作　　者：Balakumar S Rajan S Thirunalasundari T Jeeva S 

机构地区：[1]Department of Chemistry and Biosciences,SASTRA University,Srinivasa Ramanujan Centre.Kumbakonam- 612001,Tamil Nadu,India [2]Department of Microbiology,M.R.Government Arts College,Mannargudi.Thriuvarur District.Tamil Nadu,India [3]Department of Biotechnology,Bharathidasan University,Tiruchirappalli-620 024,Tamil Nadu.India [4]Centre for Biodiversity and Biotechnology.Department of Botany,Nesamony Memorial Christian College.Marthandam-629 165,Tamil Nadu.India

出　　处：《Asian Pacific Journal of Tropical Medicine》2011年第8期654-657,共4页亚太热带医药杂志（英文版）

摘　　要：Objective:To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. Methods:Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.Results:Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200μg/mL.MIC and MFC were high with water fraction(200μg/mL) against dermatophytic fungi used.Conclusions:Ocimum sanctum has antifungal activity,and the leaf extracts may be a useful source for dermatophytic infections.Objective:To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi. Methods:Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.Results:Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200μg/mL.MIC and MFC were high with water fraction(200μg/mL) against dermatophytic fungi used.Conclusions:Ocimum sanctum has antifungal activity,and the leaf extracts may be a useful source for dermatophytic infections.

关 键 词：Antifungal activity DERMATOPHYTOSIS Epidermophyton floccosum Minimum fungicidal CONCENTRATION MICROSPORUM SP Minimum inhibitory CONCENTRATION OCIMUM sanctum TRICHOPHYTON SP 

分 类 号：R285.5[医药卫生—中药学]