Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract  

作　　者：Sherif W. Mansour Sibghatullah Sangi Sree Harsha Mueen A. Khaleel A. R. N. Ibrahim 

机构地区：[1]Biomedical Sciences Department, College of Clinical Pharmacy, King Faisal University,KSA [2]Physiology Department, Faculty of Medicine, Zagazig University,Egypt [3]Pharmacy Practice Department, College of Clinical Pharmacy, King Faisal University,KSA [4]Pharmaceutical Sciences Department, College of Clinical Pharmacy, King Faisal University,KSA [5]Department of Biochemistry, Faculty of Pharmacy, Minia University,Minia, Egypt

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第7期563-568,共6页亚太热带生物医学杂志（英文版）

基　　金：Supported by Deanship of scientific research,King Faisal University,KSA(Grant no.170323-2012)

摘　　要：Objective:To clarify the modulatory effects of daily consumption of pomegranate extract(PE),olive oil(OO)andNagilla sativaoil(NSO)on antioxidant activity,sperm quality and pituitary-testicular axis of adult male wistar rats.Methods:Thirty-two adult male Wistar rats were dividedinto four equal groups,eight rats each.Using rat gastric tubes,1.0 mL distilled water,1.0 mL PE,0.4mL NSO and 0.4 mL OO were orally administered daily for 6 weeks in the first,second,third andfourth groups,respectively.Reproductive organs,body weight,sperm criteria,testosterone,FSH,LH,inhibin-B,lipid peroxidation,and antioxidant enzyme activities were investigated.At the endof the study protocol,analyses occurred at the same time.Data were analysed by ANOVA test and P<0.05 was considered to be a significant value.Results:In all studied groups,malondialdehydelevel was significantly decreased accompanied with an increases in glutathione peroxidase andglutathione.Rats treated with PE showed an increase in catalase activities accompanied withan increase in sperm concentration which was also observed in NSO group.In PE treated group,sperm motility was also increased accompanied with decreased abnormal sperm rate.NSO,OOand PE treated groups shows an insignificant effect on testosterone,inhibin-B,FSH and LH incomparison with control group.Conclusions:These results show that administration of PE,NSOand OO could modify sperm characteristics and antioxidant activity of adult male wistar rats.Objective:To clarify the modulatory effects of daily consumption of pomegranate extract(PE),olive oil(OO)andNagilla sativaoil(NSO)on antioxidant activity,sperm quality and pituitary-testicular axis of adult male wistar rats.Methods:Thirty-two adult male Wistar rats were dividedinto four equal groups,eight rats each.Using rat gastric tubes,1.0 mL distilled water,1.0 mL PE,0.4mL NSO and 0.4 mL OO were orally administered daily for 6 weeks in the first,second,third andfourth groups,respectively.Reproductive organs,body weight,sperm criteria,testosterone,FSH,LH,inhibin-B,lipid peroxidation,and antioxidant enzyme activities were investigated.At the endof the study protocol,analyses occurred at the same time.Data were analysed by ANOVA test and P&lt;0.05 was considered to be a significant value.Results:In all studied groups,malondialdehydelevel was significantly decreased accompanied with an increases in glutathione peroxidase andglutathione.Rats treated with PE showed an increase in catalase activities accompanied withan increase in sperm concentration which was also observed in NSO group.In PE treated group,sperm motility was also increased accompanied with decreased abnormal sperm rate.NSO,OOand PE treated groups shows an insignificant effect on testosterone,inhibin-B,FSH and LH incomparison with control group.Conclusions:These results show that administration of PE,NSOand OO could modify sperm characteristics and antioxidant activity of adult male wistar rats.

关 键 词：POMEGRANATE EXTRACT Nagilla sativaoil Olive OIL Testosterone FSH LH Inhibin-B Lipid PEROXIDATION Sperm characteristics Antioxidant enzymes 

分 类 号：R285[医药卫生—中药学]