An overall assessment of circumanal gland adenoma in a terrier mix breed dog  

作　　者：Javad Javanbakht Abbas Tavassoli Farhang Sasani Atefeh Sabbagh Mehdi Aghamohamad Hassan Shohreh Alian Samakkhah Radmehr Shafiee Meysam Jani Samad Alimohammadi Reza Samani Fardin Barati Vahideh Rahmani Ghalee 

机构地区：[1]Department of Pathology, Faculty of Veterinary Medicine, Tehran University,Tehran, Iran [2]Department of Clinical Science, Faculty of Veterinary Medicine, Tehran University,Tehran, Iran [3]Department of Health Food Hygiene, Faculty of Veterinary Medicine, Tehran University,Tehran, Iran [4]Graduate Faculty of Veterinary Medicine, Tehran University,Tehran, Iran [5]Department of Physiology, Faculty of Veterinary Medicine, Tehran University,Tehran, Iran

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第7期580-583,共4页亚太热带生物医学杂志（英文版）

摘　　要：In September 2012,a 10-year-old,intact male,terrier mix breed dog was evaluated because ofmultiple,0.5 to 1.2 cm in diameter,round,intradermal nodules around the anus.It had surgery toexcise a firm,painful swelling in the left ventrolateral perianal region and the excision part wasobserved under light microscopy.The mass spreading in to sub acute was of left hind leg out fromthe ventro-lateral of anus,1.2 cm伊1 cm/0 cm伊0.5 cm in size and 125 g in weight.A completeblood cell count,serum biochemistry panel,and urinalysis(cystocentesis sample)were evaluated.Significant laboratory data demonstrated microcytic anemia(hemoglobin of 6.4 mg/dL)and normalcoagulation times.No remarkable abnormalities were found in the complete blood count and anionized calcium of 1.91 mmol/L(reference range,1.1-1.3 mmol/L)was confirmed hypercalcemia.On cytologic and histopathologic examinations,evaluation of the aspirate revealed a prominentpopulation of round-to-polygonal nucleated cells arranged as cohesive groups with isolatedindividual cells.A mild degree of anisocytosis and anisokaryosis was observed.In addition,smaller reserve type cells,with darker cytoplasm and a higher nucleocytoplasmic ratio.Theadenomas generally retain the lobular architecture,but some may contain focal areas of cellularpleomorphism.These changes may suggest malignant transformation and have led to discordantinterpretations,the well-developed stroma surrounding the lobules and hepatoid cells was noted.Ulceration,hemorrhage,necrosis and secondary infection with inflammatory cell infiltrates arecommon.These cytology and histopathology features are consistent with hepatoid gland adenoma.In September 2012, a 10-year-old, intact male, terrier mix breed dog was evaluated because ofmultiple, 0.5 to 1.2 cm in diameter, round, intradermal nodules around the anus. It had surgery toexcise a firm, painful swelling in the left ventrolateral perianal region and the excision part wasobserved under light microscopy. The mass spreading in to sub acute was of left hind leg out fromthe ventro-lateral of anus, 1.2 cm伊1 cm/ 0 cm伊0.5 cm in size and 125 g in weight. A completeblood cell count, serum biochemistry panel, and urinalysis(cystocentesis sample) were evaluated.Significant laboratory data demonstrated microcytic anemia(hemoglobin of 6.4 mg/dL) and normalcoagulation times. No remarkable abnormalities were found in the complete blood count and anionized calcium of 1.91 mmol/L(reference range, 1.1-1.3 mmol/L) was confirmed hypercalcemia.On cytologic and histopathologic examinations, evaluation of the aspirate revealed a prominentpopulation of round-to-polygonal nucleated cells arranged as cohesive groups with isolatedindividual cells. A mild degree of anisocytosis and anisokaryosis was observed. In addition,smaller reserve type cells, with darker cytoplasm and a higher nucleocytoplasmic ratio. Theadenomas generally retain the lobular architecture, but some may contain focal areas of cellularpleomorphism. These changes may suggest malignant transformation and have led to discordantinterpretations, the well-developed stroma surrounding the lobules and hepatoid cells was noted.Ulceration, hemorrhage, necrosis and secondary infection with inflammatory cell infiltrates arecommon. These cytology and histopathology features are consistent with hepatoid gland adenoma.

关 键 词：Hepatoid GLAND ADENOMA CYTOLOGY HISTOPATHOLOGY DOG Blood cell count 

分 类 号：S858.292[农业科学—临床兽医学]