Evaluation of larvicidal activity of Pongamia pinnata extracts against three mosquito vectors  

作　　者：Guna Ranjan Kolli Balakrishnan Vijayan Raja Sundararajan 

机构地区：[1]GITAM Institute of Pharmacy,GITAM University [2]National Centre for Disease Control(Formely Southern India Branch,NICD) [3]Department of Pharmaceutical Biotechnology,J.S.S College of Pharmacy

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第11期853-858,共6页亚太热带生物医学杂志（英文版）

基　　金：Foundation Name and Grant No:AICTE/QIP/09/2009/059

摘　　要：Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata(P.pinnata)extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested against fourth instar larvae of Culex quinqnefasciatus,Aedes aegypti and Anopheles stephensi.The mortality was observed 24 h and 48 h after treatment,data was subjected to probit analysis to determine lethal concentration(LC_(50)and LC_(90))to kill 50 and 90 percent of treated larvae of tested species.Results:The larval mortality was found in both methanol and hydroalcohol extracts of P.pinnata against Culex quinquefascialus,Aedes aegypti and Anopheles stephensi with LC_(50)values of 84.8,118.2 and 151.7 ppm;97.7,128.3 and 513 ppm.The highest larval mortality was found in methanol extract of P.pinnala when comparable to the hydroalcohol extract.Conclusions:These results suggest that both methanol and hyrdoalcohol extracts have the potential to be used as an ideal ecofriendly approach for the control of disease vectors.This could lead to isolation of novel natural larvicidal compounds.Objective:To evaluate the mosquito larvicidal activity of Pongamia pinnata（P.pinnata）extracts against three mosquito vectors.Methods:The methanol and hydroalcohol extracts of bark part of P.pinnata L were tested against fourth instar larvae of Culex quinqnefasciatus,Aedes aegypti and Anopheles stephensi.The mortality was observed 24 h and 48 h after treatment,data was subjected to probit analysis to determine lethal concentration(LC50and LC90)to kill 50 and 90 percent of treated larvae of tested species.Results:The larval mortality was found in both methanol and hydroalcohol extracts of P.pinnata against Culex quinquefascialus,Aedes aegypti and Anopheles stephensi with LC50values of 84.8,118.2 and 151.7 ppm;97.7,128.3 and 513 ppm.The highest larval mortality was found in methanol extract of P.pinnala when comparable to the hydroalcohol extract.Conclusions:These results suggest that both methanol and hyrdoalcohol extracts have the potential to be used as an ideal ecofriendly approach for the control of disease vectors.This could lead to isolation of novel natural larvicidal compounds.

关 键 词：Pongamia pinnata L. LARVICIDAL MOSQUITO vectors CULEX quinquefasciatus AEDES aegypti ANOPHELES STEPHENSI 

分 类 号：R285.5[医药卫生—中药学]