Cryptosporidiosis as threatening health problem:A review  

作　　者：Nurul Fariza Rossle Baha Latif 

机构地区：[1]Faculty of Medicine,Universiti Teknologi MARA,Jalan Hospital

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2013年第11期916-924,共9页亚太热带生物医学杂志（英文版）

基　　金：part of the project funded by MARA University of Technology Excellence Fund[Grant No.600-RMI/ST/DANA 5/3/Dst(334/2011)]

摘　　要：The protozoa under the genus Cryplosporidium is a zoonotic apicomplexan obligate intracellular parasite.Cryptosporidiosis,the term used to designate infection caused by Cryptosporidium sp.,is considered as one of the most common food and waterborne diseases with worldwide spread,acting as a common cause of diarrhoea in animals and man.In immunocompetent individuals,Cryptosporidium typically induces self-limiting diarrhoea,which may resolve on its own after 2-3d.However,cryptosporidiosis may turn life-threatening and subsequently lead to death in small children,the elderly and immunocompromised person,especially in AIDS patient.The diagnosis for Cryptosporidium infection is usually carried out through examination of stool for the presence of oocysts which measured 4-6μm with spherical appearance.Morphometric identification is often difficult because of the diminutive size and obscure internal structure of the protozoa.Often,the identification of Cryptosporidium is realised through the combination of methods incorporating data from morphometries,molecular techniques,and host specificity.However,limitations to some of these techniques still exist whether because of eost,duration,expertise,or reliability.Drugs combination is implemented in treatment of cryptosporidiosis.The efficiency of paromomycin,an aminocyclitol antibiotic isolated from Streptomyces,can be effective when combined use with protease inhibitors or recombinant IL-12.Since there is no drug that achieves the complete removal of Cryptosporidium from the host,supportive therapy was preferred in both human and domestic animals.The protozoa under the genus Cryplosporidium is a zoonotic apicomplexan obligate intracellular parasite.Cryptosporidiosis,the term used to designate infection caused by Cryptosporidium sp.,is considered as one of the most common food and waterborne diseases with worldwide spread,acting as a common cause of diarrhoea in animals and man.In immunocompetent individuals,Cryptosporidium typically induces self-limiting diarrhoea,which may resolve on its own after 2-3d.However,cryptosporidiosis may turn life-threatening and subsequently lead to death in small children,the elderly and immunocompromised person,especially in AIDS patient.The diagnosis for Cryptosporidium infection is usually carried out through examination of stool for the presence of oocysts which measured 4-6μm with spherical appearance.Morphometric identification is often difficult because of the diminutive size and obscure internal structure of the protozoa.Often,the identification of Cryptosporidium is realised through the combination of methods incorporating data from morphometries,molecular techniques,and host specificity.However,limitations to some of these techniques still exist whether because of eost,duration,expertise,or reliability.Drugs combination is implemented in treatment of cryptosporidiosis.The efficiency of paromomycin,an aminocyclitol antibiotic isolated from Streptomyces,can be effective when combined use with protease inhibitors or recombinant IL-12.Since there is no drug that achieves the complete removal of Cryptosporidium from the host,supportive therapy was preferred in both human and domestic animals.

关 键 词：CRYPTOSPORIDIUM PREVALENCE TAXONOMY OUTBREAK Diagnosis 

分 类 号：R519[医药卫生—内科学]