Hepatoprotective activity of Musa paradisiaca on experimental animal models  

作　　者：Nirmala M Girija K Lakshman K Divya T 

机构地区：[1]Department of Pharmacognosy,PES College of Pharmacy

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2012年第1期11-15,共5页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To invesligale the hepatoprotective activity of stem of Musa paradisiaca(M.paradisiaca)in CCl_4 and paracetamol induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of alcoholic and aqueous extracts of stem of M.paradisiaca was demonstrated by using two experimentally induced hepatotoxicity models.Results:Administration of hepatotoxins(CCl_4 and paracetamol)showed significant biochemical and histological deteriorations in the liver of experimental animals.Pretreatment with alcoholic extract(500 mg/kg),more significantly and to a lesser extent the alcoholic extract(250 mg/kg)and aqueous extract(500 mg/kg),reduced the elevated levels of the serum enzymes like serum glutamic-oxaloacetic transaminase(SCOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP)and bilirubin levels and alcoholic and aqueous extracts reversed the hepatic damage towards the normal,which further evidenced the hepatoprotective activity of stem of M.paradisiaca.Conclusions:The alcoholic extract at doses of 250 and 500 mg/kg,p.o.and aqueous extract at a dose of 500 mg/kg,p.o.of stem of M.paradisiaca have significant effect on the liver of CCl_4 and paracetamol induced hepatotoxicity animal models.Objective:To investigate the hepatoprotective activity of stem of Musa paradisiaca(M. paradisiaca) in CCl_4 and paracetamol induced hepatotoxicity models in rats.Methods: Hepatoprotective activity of alcoholic and aqueous extracts of stem of M.paradisiaca was demonstrated by using two experimentally induced hepatotoxicity models.Results: Administration of hepatotoxins(CCl_4 and paracetamol) showed significant biochemical and histological deteriorations in the liver of experimental animals.Pretrealment with alcoholic extract(500 mg/kg),more significantly and to a lesser extent the alcoholic extract(250 mg/kg) and aqueous extract(500 mg/kg),reduced the elevated levels of the serum enzymes like serum glutamic-oxaloacetic transaminase(SCOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP) and bilirubin levels and alcoholic and aqueous extracts reversed the hepatic damage towards the normal,which further evidenced the hepatoprotective activity of stem of M. paradisiaca.Conclusions:The alcoholic extract at doses of 250 and 500 mg/kg,p.o.and aqueous extract at a dose of 500 mg/kg,p.o.of stem of M.paradisiaca have significant effect on the liver of CCl,and paracetamol induced hepatotoxicity animal models.

关 键 词：MUSA paradisiaca SGPT SGOT ALP Direct BILIRUBIN Total BILIRUBIN HISTOPATHOLOGY 

分 类 号：R285.5[医药卫生—中药学]