记忆与学习的脑化学研究——海马内注射胰蛋白酶与核糖核酸酶对大白鼠暗箱回避模式记忆的影响  

BRAINCHEMICAL STUDY OF MEMORY AND LEARNING:Ⅰ.INJECTION OF PANCREATIC TRYPSIN AND RIBONUCLEASE INTO THE HIPPOCAMPUS AND ITS INFLUENCE ON MEMORY OF DARK BOX AVOIDANCE MODEL OF ALBINO RATS

作　　者：罗胜德 李德明[1] 孙丽华[1] 

机构地区：[1]中国科学院心理研究所

出　　处：《心理学报》1979年第1期65-76,共12页Acta Psychologica Sinica

摘　　要：问题的提出 记忆与学习的规律及其脑机制的研究,历来是生理心理学中最为活跃而富有成效的研究领域之一。随着分子生物学、神经化学与脑科学研究的近代进展,“记忆之谜”——特别是记忆与学习的脑化学基础(分子基础),正越来越引起心理学、生物学、医药学及有关研究者们的广泛重视与热烈讨论。本世纪三十年代。A new approach was proposed in which a memory model was studiedwith the method of instrumental enzyme drugs. Two instrumental enzymes, bovine pancreatic Trypsin and RNase, wereselected which are capable of destroying some types of proteins and RNA.A total of 60 adult albino rats, each implanted two pairs of brain canals,were divided into two groups: a non-consolidation group （NC） and a cons-olidation group （C）. Each group was again divided into three sub-groupsof Trypsin （T）, RNase （R） and normal saline salution （NS）. The resultsshowed that after different periods of bilateral injection of Trypsin andRNase into the hippocampus （iH）, different effects were observed on theconditioned reflex of DBA memory model(CR_DBA). 72 hours after injectionof Trypsin （AP₂L₂H₄ and AP₄L₃H₅） retention of DBA memory clearlydecreased in the NC group, and the amnesia effect under this experimentalcondition contrasted with the other conditions in that their differences werestatistically significant. The paper discussed on some possible causes of the above phenomenonas well as the significance of the experimental findings. The authors wereof the opinion that if instrumental enzyme drugs with clearly demonstratedactive mechanisms could be selected systematically and to pursue furtherresearch into the influences of drugs on the consolidation of different levelsof memory model, it would be of benefit to the understanding of the bra-inchemical mechanism of memory. At least this would be a new line ofapproach that is worth exploration.

关 键 词：脑化学 核糖核酸酶 海马内注射 模式记忆 大白鼠 生理心理学 脑科学研究 胰蛋白 神经化学 脑机制 

分 类 号：B[哲学宗教]