卡介菌多糖核酸治疗变应性鼻炎的临床观察  

THE CLINIC STUDY OF POLYSACCHARIDE NUCLEIC ACID OF BACILLUS CALMETTE GUERIN(BCG - PSN) IN TREATING ALLERGIC RHINITIS

作　　者：殷泽登[1] 黎万荣[1] 欧小毅[1] 吴跃军[1] 白国荣[1] 杨利[1] 

机构地区：[1]泸州医学院附属医院耳鼻咽喉一头颈外科,四川省泸州市646000

出　　处：《中国煤炭工业医学杂志》2004年第9期809-810,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察卡介菌多糖核酸治疗变应性鼻炎的临床疗效,并探讨其免疫学机制。方法对25例变应性鼻炎患者采用卡介菌多糖核酸注射液1ml肌注,隔日1次,疗程为6周。观察其临床疗效。对照组25例采用必可酮局部治疗。结果 临床近期疗效:卡介菌多糖核酸治疗后1周的显效率为72.0％,总有效率为96.0％;对照组治疗后1周的总有效率为92.O％。随访2个月后再次进行疗效评定:卡介茵多糖核酸组的显效率为60.0％,总有效率为88.0％。对照组显效率为44.0％,总有效率为76.0％。本组病例无一例出现不良反应。二组比较,卡介菌多糖核酸组显效率明显优于对照组(P<0.01),总有效也高于后者。结论卡介菌多糖核酸对变应性鼻炎具有较好的治疗作用,不良反应少。Objective To study the effect and the mechanism of BCG-PSN on allergic rhinitis. Methods All patients were divided into two groups at random. 25 patients was treated by adopting BCG- PSN 1ml for 6 weeks and the other group was treated by adopting Beclomethasone Dipropionas. Results After one week, the treatment group showed efficiency as 72. 0% ,the gross efficiency rate was 96.0% .The gross efficiency rate of the control group was 92% .After two weeks, the treatment group showed efficiency as 60.0% and the gross efficiency rate was 88.0% . The control group showed efficiency as 44. 0% and the gross efficiency rate was 76% .With chi-square test,P<0.01. Conclusion It is an effective method by adopting BCG- PSN in treating allergic rhinitis.

关 键 词：变应性鼻炎 卡介菌多糖核酸 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]