髓过氧化物酶基因多态性与冠心病易感性的Meta分析(英文)  

Meta-analysis of myeloperoxidase gene polymorphism and coronary artery disease susceptibility

作　　者：陈璐瑶[1] 赵树山[1] 成光杰[1] 石瑞正[1] 张国刚[1] 

机构地区：[1]中南大学湘雅医院心血管内科,长沙410008

出　　处：《中南大学学报（医学版）》2014年第3期217-231,217,共15页Journal of Central South University ：Medical Science

基　　金：supported by the National Natural Science Foundation of China(81170261,81102440);China Hunan Provincial Science and Technology Department(2011JJ4019-12,2013Fj4115)

摘　　要：目的:分析髓过氧化物酶(myeloperoxidase,MPO)基因多态性与冠心病易感性的关系.方法:利用多个网络数据库及相应关键词检索自建库以来至2013年3月的相关文献.用Stata12.0对纳入文献的相关数据进行Meta分析,评估相对危险度(odds ratio,OR值)及95％置信区间(confidence interval,CI).同时,对文献中各研究的异质性及敏感性进行分析.发表偏倚通过Begg's漏斗图和Egger's线性回归图进行检测.结果:共纳入17篇文献,Meta分析显示各基因型合并后的OR值及95％CI,其中在MPO-463 G/A基因中,A等位基因与G等位基因比较,OR=0.58,95％ CI (0.47～0.72);基因型AA+AG与GG比较,OR=0.58,95％ CI (0.46～0.72).在欧洲人群亚组中,AA+AG对GG的OR=0.79,95％ CI (0.58～1.08);在稳定型心绞痛亚组中,A对G的OR=0.45,95％ CI (0.15～1.37); AA+AG对GG的OR=0.57,95％ CI (0.19～1.65).在MPO-129 A/G基因中,GG对AA+AG的OR=0.91,95％ CI (0.74～1.10).结论:除欧洲人群外,携带MPO-463 G/A基因中A等位基因者冠心病的发病风险降低,MPO-129 A/G基因与冠心病易感性无相关性.Objective: To assess the association between myeloperoxidase(MPO) gene polymorphism and coronary artery disease(CAD). Methods: Several databases were used to retrieve relevant literature up to March 2013 by keywords. A Meta-analysis was performed by Stata12.0 sot ware to estimate the pooled odds ratio(OR) and the 95% coni dence interval(CI). Heterogeneity among studies was tested and sensitivity analysis was applied. Publication bias was examined using Begg's funnel plot and Egger's linear regression test. Results: A total of 17 studies were included in this Meta-analysis. For MPO-463 G/A polymorphism, the pooled OR of A allele vs G allele was 0.58 [95% CI(0.47-0.72)] and the pooled OR of genotypes AA+AG vs GG was 0.58 [95% CI(0.46-0.72)]. In subgroup analysis of study population, AA and AG genotypes were significantly associated with CAD in Asians but not in Europeans. The MPO-463 G/A polymorphism in the stable angina pectoris subgroup was evaluated in 3 studies and the pooled OR of A allele vs G allele and genotypes AA+AG vs GG for proven CAD was 0.45 [95% CI(0.15-1.37)] and 0.57 [95% CI(0.19-1.65)]. For MPO-129 A/G gene polymorphism, the pooled OR of genotype GG vs AA+AG was 0.91 [95% CI(0.74–1.10)]. Conclusion: A allele of MPO-463 G/A gene is associated with decreased risk of CAD except in the Europeans. There is no association between MPO-129 A/G gene polymorphisms and CAD risk.

关 键 词：冠心病 髓过氧化物酶 基因多态性 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]