阿伦磷酸钠含量对骨水泥静态机械性能的影响  

Ef ect of alendronate amount on the static mechanical properties of bone cement

作　　者：宋德业[1] 倪江东[1] 毛新展[1] 丁木亮[1] 

机构地区：[1]中南大学湘雅二医院骨科,长沙410011

出　　处：《中南大学学报（医学版）》2014年第2期178-184,共7页Journal of Central South University ：Medical Science

摘　　要：目的:观察阿伦磷酸钠含量对骨水泥浸提前、浸提4周后静态机械性能的影响,从生物力学角度确定阿伦磷酸钠的合适加入量.方法:在50 g Cemex(R)XL骨水泥粉末中分别加入0,10,50,100,500,1 000 mg阿伦磷酸钠制备标本(依次命名为G0～G5组).万用测试仪测定各组骨水泥浸提前、浸提4周后的压缩强度、弯曲强度(模量);扫描电子显微镜观察部分标本断面,显微CT测定标本孔隙率.结果:各组骨水泥浸提前、浸提4周后及浸提前后压缩强度差异无统计学意义(P＞0.05);与G0组比较,浸提前或浸提4周后G1～G4组弯曲强度或弯曲模量均无明显改变(p＞0.05),而与G5组弯曲强度有明显差异(P＜0.05);G5组浸提4周后弯曲模量与G0组差异有统计学意义(P＜0.05);各组浸提前后弯曲强度差异均无统计学意义(P＞0.05);各组浸提前弯曲模量差异无统计学意义(P＞0.05),浸提前后弯曲模量差异有统计学意义(P＜0.05).结论:50g骨水泥粉末中阿伦磷酸钠加入量不超过500 mg对浸提前,浸提4周后的静态机械性能无明显影响.Objective: To determine the effect of alendronate amount on the static mechanical properties of bone cement before elution and 4 weeks after elution, and determine suitable amount of alendronate in cement from the perspective of biomechanics. Methods: Samples of compression strength and bending strength(modulus) were prepared with bone cement adding 0, 10, 50, 100, 500 and 1000 mg alendronate in 50 g Cemex?XL bone cement powders respectively(named as G 0 –G 5 groups). The compression strength, bending strength, and bending modulus of bone cement were examinated by INSTRON 8032 tester before the elution and 4 weeks at er the elution. Some broken samples of 4-point bending test were examinated by scanning electronic microscopy(SEM), and some other samples of bending strength(modulus) tests by micro-CT. Results: No significant difference was found in the compression strength before the elution,4 weeks after elution in the 6 groups, and before and after the elution in the respective groups(P>0.05). Compared with G 0 group, G 1 –G 4 groups had no obvious difference in the bending strength before the elution and 4 weeks at er the elution(P>0.05), while G 5 group had dif erence(P<0.05). h ere was no signii cant dif erence in the bending strength before and at er the elution in the respective groups(P>0.05). Taken G 0 group as the control group, G 1 –G 4 groups had no visible effects on the bending modulus 4 weeks after the elution(P>0.05), while G 5 group decreased it signii cantly(P<0.05). Bending modulus before the elution in the 6 groups didn't show obvious dif erence(P>0.05), while bending modulus before and at er the elution in the respective groups displayed a marked dif erence(P<0.05). Conclusion: Less than 500 mg alendronate added in Cemex?XL 50 g bone cement powder does not decrease the compressive strength, l exural strength and l exural modulus before the elution and 4 weeks at er the elution.

关 键 词：阿伦磷酸钠 二磷酸盐 骨水泥 静态机械性能 

分 类 号：R687.4[医药卫生—骨科学]