IgA肾病免疫机制与治疗靶点研究进展  

Immune pathogenesis of IgA nephropathy and its drugable targets

作　　者：贺理宇[1] 刘虹[1] 彭佑铭[1] 

机构地区：[1]中南大学湘雅二医院肾内科,长沙410011

出　　处：《中南大学学报（医学版）》2014年第1期96-101,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81170663;81373227);湖南省自然科学基金(12JJ6094)~~

摘　　要：IgA肾病是全球最常见的免疫相关性肾小球疾病,以肾小球系膜区低糖基化IgA1沉积为主要病理特征。免疫调节紊乱在IgA肾病发病机制中起着重要的作用。T和B淋巴细胞的活化异常,可导致机体产生大量的低糖基化IgA1。IgA nephropathy(IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide.The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli.Dysregulation of the immune system plays an important role in the pathogenesis of IgAN.Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.

关 键 词：IGA肾病 免疫学 分子机制 治疗靶点 

分 类 号：R692.3[医药卫生—泌尿科学]