待肾移植患者白细胞滤过输血的临床应用  

Clinical Application of Transfusion of Leukocyte Filtering on Patients Waiting for Kidney Transplantation

作　　者：赵兴华[1] 谭春泽[2] 吴书一[1] 王志余[1] 

机构地区：[1]郑州市第三人民医院,郑州市450000 [2]中国人民解放军181医院中心实验室,桂林市541002

出　　处：《医药论坛杂志》2004年第13期19-20,22,共3页Journal of Medical Forum

摘　　要：目的　探讨白细胞滤过输血对待肾移植患者产生HLA抗体的影响及巨细胞病毒 (CMV)感染率的降低程度。方法　选择 16 6例待肾移植患者进行临床输血观察 ,其中 92例进行白细胞滤过输血 ,74例进行浓缩红细胞输注。结果　白细胞滤过组 ,HLA抗体阳性率 1.1% ,巨细胞病毒感染率 3.2 % ;未滤过组HLA抗体阳性率 9.5 % ,巨细胞病毒感染率 13.5 % ;两者差别有高度显著性 (P <0 .0 1)。结论　白细胞滤除输血 ,能够有效预防HLA抗体产生 ,减少肾移植术后CMV感染 ,对确实需输血的待肾移植患者提供了一条安全有效的输血途径和措施。Objective To investigate the effect of HLA-IgG and cytomegalovirus infection about transfusion of leukocyte filtering on the patients waiting for kidney transplantation. Methods A total of 166 patients waiting for kidney transplantation were divided into two groups, 92 cases were transfusion of leukocyte filtering, 74 cases were transfusion of concentrated red cells. Results In leukocyte filtering group,the HLA antibody positive rate 1.1%,the cytomtgalovirus infection rate is 3.2 %,the non-filtering group HLA antibody positive rate is 9.5%,the cytomegalovirus infection rate is 13.5%,there's obvious difference between them(P<0.01). Conclusion This method can effectively prevent HLA antibody production,lessen CMV infection.It was a security transfusion pathway to the patient waiting for kidney transplantation by transfusion of leukocyte filtering.

关 键 词：输血 白细胞滤过 肾移植HLA抗体 巨细胞病毒感染 

分 类 号：R457.1[医药卫生—治疗学] R692[医药卫生—临床医学]