接触芳香烃类作业人员职业健康的早期指标  

Early Health Care Indicators for Workers Exposed to Aromatic Hydrocarbons

作　　者：肖太钦[1] 

机构地区：[1]胜利油田疾病预防控制中心

出　　处：《环境卫生学杂志》2014年第1期54-56,64,共4页JOURNAL OF ENVIRONMENTAL HYGIENE

摘　　要：目的通过对长期接触芳香烃类有害物质作业人员的健康监护早期指标的研究,动态监护此类作业人员体内氧化应激状态,及时掌握人体损伤程度,为早期采取干预措施提供技术依据。方法采用比色法检测血清中丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)及超氧化物歧化酶(SOD)的含量。结果实验组和对照组血清中MDA平均值分别为4.46 nmol/mL和2.01 nmol/mL;实验组和对照组GSH-PX平均值分别为272.2 U/mL和312.5 U/mL;实验组和对照组SOD平均值分别为110.0 U/mL和97.5 U/mL(P<0.05)。结论长期接触芳香烃类有害物质可使机体内自由基含量增高,体内氧化应激状态加剧,表明血清中MDA及SOD含量可作为该作业人群健康监护的早期指标。Objectives To study the early indicators for the health care of workers with long-term exposure to harmful aromatic hydrocarbon substances,to dynamically monitor the oxidative stress status and timely grasp the degree of injury in human body, so as to provide technical basis for taking early intervention measures. Methods The content of serum malondialdehyde( MDA) and the activities of glutathione peroxidase( GSH-PX) and superoxide dismutase( SOD) were detected by colorimetric method. Results The mean values of serum MDA in the exposure group and control group were 4. 46 nmol / mL and 2. 01 nmol / mL,respectively; the mean activities of GSH-PX were 272. 2 U / mL and 312. 5 U / mL,respectively; and the mean activities of SOD were 110. 0 U / mL and 97. 5 U / mL,respectively( P < 0. 05). Conclusions Long-term exposure to harmful aromatic hydrocarbon substances could increase the level of free radicals in human body and enhance the oxidative stress status in vivo. The results indicated that the content of MDA and the activity of SOD in serum could be used as early indicators for monitoring the health status of workers exposed to aromatic hydrocarbon environment.

关 键 词：芳香烃类 职业健康监护 早期指标 

分 类 号：R131[医药卫生—劳动卫生]