多指标综合评分法优选痹痛灵软膏的提取工艺  

Study on Optimal Extraction Process of Bitongling Ointment by Multi-index Compositive Score Method

作　　者：张小琴[1] 徐伟[1] 李煌[1] 褚克丹[1] 陈立典[2] 

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]福建中医药大学康复医学院,福建福州350122

出　　处：《福建中医药大学学报》2014年第1期33-36,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省科技厅重大专项资助课题(2009YZ0001-1-1);"十二五"国家科技支撑计划项目资助课题(2011BAI01B05)

摘　　要：目的筛选和优化痹痛灵软膏的提取工艺。方法以雷公藤内酯醇、青藤碱和干膏率为考察指标,采用正交实验优选痹痛灵软膏的提取工艺。结果最佳工艺为A1B2C1D1,即70%乙醇、8倍量、提取2次、每次1 h。结论用正交法优选痹痛灵软膏的提取工艺稳定、可行。Objective To study the optimal extraction process of Bitongling ointment. Methods The contents of triptolide, sinomenine and dry extract from the drug were chosed as the indexes, and the optimum conditions were investigated by orthogonal test. Results The optimal extraction process was A1B2C1D1, including 8 folds amount of 70% ethanol, 2 times, and 1 hours each time. Conclusion The optimal extraction process is stable and reliable.

关 键 词：痹痛灵软膏 提取工艺 雷公藤内酯醇 青藤碱 

分 类 号：R284[医药卫生—中药学] TQ461[医药卫生—中医学]