阿米替林联合肝素膀胱灌注治疗间质性膀胱炎的疗效观察  

Therapeutic efficacy of amitriptyline and intravesical heparin instillation in patients with interstitial cystitis

作　　者：朱震平[1] 黄军成[1] 张雪燕[1] 

机构地区：[1]广东省农垦中心医院,广东湛江524002

出　　处：《广东医学院学报》2014年第1期23-25,共3页Journal of Guangdong Medical College

基　　金：湛江市科技攻关计划项目(No.2012C3104060)

摘　　要：目的观察阿米替林联合肝素治疗间质性膀胱炎的疗效及间质性膀胱炎症状指数(ICSI)、问题指数评分(ICPI)和尿频尿急症状评分(PUF)的影响。方法间质性膀胱炎50例患者随机等分为2组:对照组予阿米替林口服,实验组予阿米替林口服+肝素膀胱灌注,3个月后比较两组疗效及ICSI、ICPI、PUF变化。结果实验组疗效及ICSI、PUF改善明显优于对照组(P<0.05)。结论阿米替林联合肝素治疗间质性膀胱炎的疗效优于单用阿米替林。Objective To observe therapeutic efficacy of amitriptyline and intravesical heparin instillation in patients with interstitial cystitis and their effect on interstitial cystitis symptom index(ICSI), interstitial cystitis problem index(ICPI), and pelvic pain urgency/frequency(PUF) scale. Methods Fifty cases of interstitial cystitis were equally divided into 2 groups. Control group received oral amitriptyline, while experimental group were treated with oral amitriptyline and intravesical heparin instillation. Therapeutic efficacy, ICSI, ICPI and PUF were compared between both groups after 3-month treatment. Results Therapeutic efficacy and improvement of ICSI and PUF in the experimental group were superior to those in the control group(P<0.05). Conclusion Combined use of amitriptyline and heparin is more effective than single application of amitriptyline in patients with interstitial cystitis.

关 键 词：间质性膀胱炎 阿米替林 肝素 

分 类 号：R694.3[医药卫生—泌尿科学]