维生素D对新发2型糖尿病患者胰岛β细胞早相分泌功能及胰岛素抵抗的影响  

The changes and significance of Vitamin D in newly diagnosed type 2 diabetes mellitus patients

作　　者：邱云霞[1] 王振青 赵桂东[1] 徐涛[1] 曲燕[1] 王霞[1] 陈虹[1] 高玉霞[1] 王颜刚[3] 

机构地区：[1]胜利石油管理局胜利医院内分泌科,山东东营257055 [2]东营市人民医院 [3]青岛大学附属医院内分泌科

出　　处：《中国老年学杂志》2014年第4期886-887,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助课题(30900641);国家科技部国际合作专项基金资助课题(2012DFA31461)

摘　　要：目的观察新发男性2型糖尿病患者血清25-羟维生素D(25OHD)水平与胰岛β细胞早相分泌功能及胰岛素抵抗之间的关系。方法随机选取初诊男性2型糖尿病患者86例为糖尿病组,健康男性58名为对照组,测定血清25OHD、糖化血红蛋白(HbA1c)、空腹血糖(FPG)水平,同期进行精氨酸-胰岛素兴奋试验。结果①糖尿病组25OHD、胰岛β细胞功能指数(HOMA-β)和精氨酸-胰岛素兴奋试验6 min胰岛素均低于对照组(P<0.05);TG、FPG、HbA1c、胰岛素抵抗指数(HOMA-IR)、FPG均高于对照组(P<0.01)。②相关分析显示25OHD与HbA1c、体重指数(BMI)和HOMA-IR呈负相关(P<0.05);与胰岛素分泌的峰值倍数呈正相关;调整BMI后25OHD与HOMA-β呈正相关(P<0.05)。结论新发男性2型糖尿病患者存在维生素D缺乏;维生素D缺乏可能是导致患者胰岛β细胞早相分泌功能下降及胰岛素抵抗的原因之一。Objective To explore the relationship between serum vitamin D levels and early-phase insulin secretion or insulin resistance in newly diagnosed type 2 diabetes mellitus( T2DM) patients. Methods Methods 86 male patients with newly diagnosed T2DM were included. 58 men were recruited as healthy controls. All subjects were tested the levels of 25OHD,HbA1c,FBG. Arginine insulin stimulation test was performed for evaluation β cell insulin-secretion function. Results 25OHD,HOMA-β and the early-phaseinsulin secretion in response to Arginine stimulation were significantly lower in diabetes group compared with those of control group( P < 0. 05); conversely,the levels of TG,FPG,HbA1c,HOMA-IR,SPB were significantly higher in diabetes group( P < 0. 01). 25OHD levels were inversely correlated with HbA1c,BMI and HOMA-IR,and positively correlated with insulin peak value( P < 0. 05). 25OHD levels were positively correlated with HOMA-β even after the adjustment of BMI( P < 0. 05). Conclusions In newly diagnosed T2DM patients,serum vitamin D levels are relatively lower than those of healthy controls. The deficiency of vitamin D could be a factor leading to impairment of cell early-phase insulin-secretion and insulin resistance.

关 键 词：维生素D 早期胰岛素分泌 胰岛素抵抗 胰岛Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]