美洛昔康对慢性铝过负荷致神经元退变大鼠脑内金属离子含量的影响  

Effect of meloxicam on metal ion level of chronic aluminum overload-induced neurodegenerative rats

作　　者：苏强 杨俊卿 唐捷 

机构地区：[1]南充市中心医院药学部,四川南充637000 [2]重庆医科大学药学院药理教研室重庆市生物化学与分子药理学重点实验室

出　　处：《中国老年学杂志》2014年第4期938-940,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30672211;81070972)

摘　　要：目的观察美洛昔康对慢性铝过负荷致神经元退变大鼠脑内金属离子含量的影响。方法葡萄糖酸铝(200 mg Al3+/kg)灌胃给予Wistar大鼠,1次/d,每周连续5d,共20 w,建立慢性铝过负荷致神经元退变大鼠模型。美洛昔康(1 mg/kg和3 mg/kg),在每次给予铝盐后30 min灌胃给予。等离子体原子发射光谱检测大鼠海马金属离子含量。结果慢性铝过负荷致大鼠海马金属离子含量明显增加(P<0.05)。美洛昔康给予能明显阻遏慢性铝过负荷诱导的海马金属离子含量增加(P<0.05,P<0.01)。结论美洛昔康对慢性铝过负荷致神经元退变大鼠海马金属离子含量增加有明显抑制作用。Objective To investigate the effect of meloxicam on metal ion level( Cu,Zn,Mn,Fe,Al) of chronic aluminum overloadinduced neurodegenerative rats. Methods The neurodegeneration models of Wistar rats were established via intragastric administration of aluminum gluconate( 200 mg / kg Al3 +),once a day,5 d a week for 20 weeks. Meloxicam( 1 mg / kg and 3 mg / kg) was intragastrically( i. g) administered 30 min after each aluminum administration. The brain metal ion level was detected by ICP-AES. Results Hippocampal neurons in model rat showed obviously karyopycnosis. The brain metal ion level was obviously increased,Meloxicam obviously protected rats from learning and memory function impairment and neuron death,decreased brain metal ion level. Conclusions Meloxicam might decrease brain metal ion level of neurodegeneration induced by chronic aluminum overload in rats.

关 键 词：神经元退变 金属离子 美洛昔康 铝过负荷 

分 类 号：R965[医药卫生—药理学]