特发性突聋患者听阈与血浆胆固醇水平的相关性研究  

Study on relationship of sudden deafness patients' auditory threshold with plasma cholesterol

作　　者：朱能 应根东 龙益兴 

机构地区：[1]永康市第一人民医院,浙江永康321300

出　　处：《浙江医学教育》2012年第1期51-53,共3页Zhejiang Medical Education

摘　　要：目的:探讨特发性突聋患者听阈与血浆胆固醇水平的相关性。方法:选取我科诊治的28例特发性突聋患者作为实验组,以健康志愿人群28例为对照组。2组患者均检测血浆胆固醇(CHOL)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及血浆甘油三酯(TG)水平,并进行比较。将各临床指标与患者听阈进行直线回归和相关分析及逐步回归分析。结果:与对照组相比,实验的CHOL、LDL及TG明显较高(P<0.05),而HDL明显较低(P<0.05)。听阈与CHOL、LDL呈正相关,与HDL呈负相关(P<0.05),与TG无显著相关性(P>0.05);而多元回归分析显示听阈仅与LDL正相关。结论:血浆LDL水平升高是诱发特发性突聋的危险因素之一,LDL含量检测可作为反映特发性突聋患者耳聋程度的客观指标。[Objective] To analyze the relationship of idiopathic sudden sensorinerual heating loss(ISSHL) patients' auditory threshold with plasma cholesterol.[Method] 28 patients with ISSHL in our hospital were collected to investigation group and 28 healthy volunteers were chosen to control group.The plasma level of CHOL,LDL,HDL and TG was determined and compared between these two groups.The multiple linear regression and correlation were analyzed between above clinical indexes and auditory threshold.[Result] Compared to control group,the plasma level of CHOL,LDL and TG in investigation group were higher(P<0.05),but the plasma level of HDL was lower(P<0.05).The analysis of linear regression and correlation showed that there was a positive correlation between CHOL,LDL and auditory threshold,a negative correlation between HDL and auditory threshold(P<0.05),but no correlation between TG and auditory threshold(P>0.05).The positive correlation was between LDL and auditory threshold by multiple linear regression analysis(P<0.05).[Conclusion] An ascend plasma level of LDL was one of the risk factors inducing ISSHL.The plasma level of LDL could be used as clinical objective indicator of auditory threshold degree in patients suffered from ISSHL.

关 键 词：特发性突聋 听阈 血浆胆固醇 低密度脂蛋白 高密度脂蛋白 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]