以颅脑伤为主的多发伤患者血清NSE和MBP的检测及意义  

Measurement of NSE and MBP serum levels in multiple trauma patients with brain contusion and laceration

作　　者：李永领[1] 朱烈烈[1] 张荣[1] 陈大庆[1] 

机构地区：[1]温州医学院附属第二医院,浙江温州325027

出　　处：《浙江医学教育》2012年第3期39-41,共3页Zhejiang Medical Education

摘　　要：目的:探讨颅脑伤为主多发伤患者血清神经元特异性烯醇化酶(NSE)和碱性髓鞘蛋白(MBP)的变化及其临床意义。方法:以正常体检组为对照,用酶联免疫吸附法(ELISA)测定40例颅脑伤为主多发伤患者的血清NSE和MBP含量。结果:与对照组相比,颅脑伤为主多发伤患者伤后24小时NSE和MBP水平明显升高,分别为22.85±5.74 ng/ml和12.30±3.29ng/ml(P<0.01),在不同GCS评分各组患者之间NSE和MBP均不同(P<0.01);不同ISS评分患者NSE和MBP水平无差异(P>0.05)。结论:NSE和MBP可以作为判断以颅脑伤为主多发伤患者脑挫伤病情严重程度和评估预后的指标。[Objective] To investigate the relationship between the serum concentration of neuron-specific enolase(NSE) and myelin basic protein(MBP) in multiple trauma patients with brain contusion and laceration;and its clinical significance.[Method] Serum levels of NSE and MBP were measured in 40 multiple trauma patients with brain contusion and laceration by ELISA method.[Result] The serum level of NSE and MBP were significantly higher in multiple trauma patients with brain contusion and laceration than in normal group within 24 hours(P< 0.01). The serum concentration of NSE and MBP in patients were 22.85±5.74ng/ ml and 12.30±3.29ng/ ml,respectively.The serum level of NSE and MBP had significant difference in patients with different GCS(P<0.01).There were not significant differences about serum NSE and MBP levels of different ISS group patients(p>0.05).[Conclussion] Early elevated NSE and MBP levels in serum may reflect the severity of brain damage of multiple trauma patients with brain injury.They may be important indicators for predicting the prognosis of multiple trauma patients with brain contusion and laceration.

关 键 词：脑损伤 神经元特异性烯醇化酶 碱性髓鞘蛋白 预后 

分 类 号：R641[医药卫生—外科学]