The one-pot process for the preparation of N-monoalkyl aromatic amines from nitroarene derivatives  

作　　者：JIA JianHong SHENG WeiJian HAN Liang LI YuJin GAO JianRong TU JunFei 

机构地区：[1]State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Science China Chemistry》2009年第12期2171-2175,共5页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 20876148)

摘　　要：A series of N-monoalkyl aromatic amines are synthesized in high yields from corresponding nitroarene derivatives,aldehydes,and ammonium formate in the presence of Pd/C as a catalyst through one-pot operations at room temperature. Both the conversion and selectivity of the process are above 80%. Optimum reaction conditions are investigated,and it is found that the optimum molar ratio of nitroarene derivatives to ammonium formate and the optimum weight ratio of nitroarene derivatives to Pd/C are 1/4 and 1/0.10,respectively. These experiments provide a novel access for N-monoalkyl aromatic amines with advantages of simplicity,high selectivity,and environmental benignity.A series of N-monoalkyl aromatic amines are synthesized in high yields from corresponding nitroarene derivatives, aldehydes, and ammonium formate in the presence of Pd/C as a catalyst through one-pot operations at room temperature. Both the conversion and selectivity of the process are above 80%. Optimum reaction conditions are investigated, and it is found that the optimum molar ratio of nitroarene derivatives to ammonium formate and the optimum weight ratio of nitroarene derivatives to Pd/C are 1/4 and 1/0.10, respectively. These experiments provide a novel access for N-monoalkyl aromatic amines with advantages of simplicity, high selectivity, and environmental benignity.

关 键 词：N-monoalkylation ONE-POT process ammonium FORMATE ALDEHYDE PD/C reduction 

分 类 号：O625.632[理学—有机化学]