Enantiopure inherently chiral calix[4]arene derivatives containing quinolin-2-yl-methanol moiety:Synthesis and application in the catalytic asymmetric addition of diethylzinc to benzaldehyde  

作　　者：MIAO Ru XU ZhenXiang HUANG ZhiTang CHEN ChuanFeng 

机构地区：[1]Beijing National Laboratory for Molecular Science,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Science China Chemistry》2009年第4期505-512,共8页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 20625206 & 20372064);the National Basic Research Project (Grant Nos. 2007CB808000 & 2008CB617501), and the Chinese Academy of Sciences

摘　　要：A series of novel N,O-type chiral ligands derived from enantiopure inherently chiral calix[4]arenes containing quinolin-2-yl-methanol moiety in the cone or partialcone conformation have been synthe-sized and characterized. Moreover,they have been applied to the catalytic asymmetric addition of diethylzinc to benzaldehyde,which represents the first example that the inherently chiral calixarene can be used as the chiral ligands for the catalytic asymmetric synthesis.A series of novel N,O-type chiral ligands derived from enantiopure inherently chiral calix[4]arenes containing quinolin-2-yl-methanol moiety in the cone or partial-cone conformation have been synthesized and characterized. Moreover, they have been applied to the catalytic asymmetric addition of diethylzinc to benzaldehyde, which represents the first example that the inherently chiral calixarene can be used as the chiral ligands for the catalytic asymmetric synthesis.

关 键 词：inherently CHIRAL CALIXARENES SYNTHESIS N O-type CHIRAL ligand asymmetric catalysis DIETHYLZINC 

分 类 号：O621.25[理学—有机化学]