An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process  

作　　者：WANG LeiLei ZHANG XiaoJing JIANG YongWen MA DaWei 

机构地区：[1]Shenyang Pharmaceutical University,Shenyang 110016,China [2]State Key Laboratory of Bioorganic Chemistry and Natural Products,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Science China Chemistry》2009年第10期1616-1621,共6页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 20621062 & 20872156)

摘　　要：3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups.3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups.

关 键 词：coupling CASCADE REACTION copper IODIDE ISOCOUMARINS 

分 类 号：O643.32[理学—物理化学]