Interspecies transmission and host restriction of avian H5N1 influenza virus  

作　　者：GAO George Fu 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI), Institute of Microbiology, Chinese Academy of Sci-ences (CAS) [2]Beijing Institutes of Life Science (BioLS), Chinese Academy of Sciences (CAS)

出　　处：《Science China(Life Sciences)》2009年第5期428-438,共11页中国科学（生命科学英文版）

基　　金：Supported by the National Basic Research Program of China (Grant Nos. 2005CB523001, 2005CB523002);National Key Technologies Research & Devel-opment Program (Grant 2006BAD06A01/ 2006BAD06A04);US National Institutes of Health (NIH) (Grant 3 U19 AI051915-05S1);the National Natural Science Foun-dation of China (Grant 30599434);GAO FG is a distinguished young investigator of the NSFC (Grant No. 30525010).

摘　　要：Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.

关 键 词：H5N1 INFLUENZA VIRUS INTERSPECIES transmission VIRUS adaptation HOST factors 

分 类 号：R511.7[医药卫生—内科学]