Enantioselective O-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime  

作　　者：HU ZeKai CUI HaiLei JIANG Kun CHEN YingChun 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry,Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Science China Chemistry》2009年第9期1309-1313,共5页中国科学（化学英文版）

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 20772084)

摘　　要：The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.

关 键 词：asymmetric organocatalysis ALLYLIC alkylation OXIME Morita-Baylis-Hillman CARBONATES 

分 类 号：O643.32[理学—物理化学]