艾司洛尔对急性心肌梗死再灌注心律失常的影响  

Effect of esmolol on reperfusion arrhythmia in patients with acute myocardial infarction

作　　者：王春梅[1] 张立新[1] 朱小玲[1] 李响[1] 刘子军[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所抢救中心,北京100029

出　　处：《心肺血管病杂志》2010年第S1期75-76,共2页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：Objective:To investigate the effect of esmolol on myocardial ischemia reperfusion arrhythmia in patientswith acute myocardial infarction.Methods:The data of 622 in-hospital patients with ST-elevation myocardial infarction were collected from database of Beijing Anzhen Hospital during 2006-2007,which acceptd reperfusion treatment.The patients divided into 2 groups:In the esmolol group,an esmolol infusion was given when the diagnosis of AMI were made.In the control group,patients were given no β-blockade before or during reperfusion treatment.Reperfusion arrhythmias were recorded.Results:In the esmolol group,there were significant decreased in the rate of venericular and atrial arrhythmia:accelerated idioventricular rhythm(P=0.016),ventricular premature(P=0.000),ventrieular taehyeadria(VT)(P=0.009),ventrieular fiblliation(VF)(P=0.016),atrial premature(P=0.002)and atrial fibrillation(P=0.000).The rate of angina after infarction(P=0.005),reinfarction(P=0.019)and in-hospital mortality(P=0.038)were decreased.But there no significant difference in the rate of sinusarrest(P=0.355),high degree AV block(P=0.236).Multivariate analysis showed that esmolol was an independent effective factor for VT,VF during reperfusion and in-hospital mortality(OR=1.025,95%CI:1.008-1.043,P=0.005).Conclusion:Treatment with esmolol were useful to reduced the reperfusion arrhythmia and play an important role in protective action,so the prognosis of AMI were improved.Objective:To investigate the effect of esmolol on myocardial ischemia reperfusion arrhythmia in patientswith acute myocardial infarction.Methods:The data of 622 in-hospital patients with ST-elevation myocardial infarction were collected from database of Beijing Anzhen Hospital during 2006-2007,which acceptd reperfusion treatment.The patients divided into 2 groups:In the esmolol group,an esmolol infusion was given when the diagnosis of AMI were made.In the control group,patients were given no β-blockade before or during reperfusion treatment.Reperfusion arrhythmias were recorded.Results:In the esmolol group,there were significant decreased in the rate of venericular and atrial arrhythmia:accelerated idioventricular rhythm(P=0.016),ventricular premature(P=0.000),ventrieular taehyeadria(VT)(P=0.009),ventrieular fiblliation(VF)(P=0.016),atrial premature(P=0.002)and atrial fibrillation(P=0.000).The rate of angina after infarction(P=0.005),reinfarction(P=0.019)and in-hospital mortality(P=0.038)were decreased.But there no significant difference in the rate of sinusarrest(P=0.355),high degree AV block(P=0.236).Multivariate analysis showed that esmolol was an independent effective factor for VT,VF during reperfusion and in-hospital mortality(OR=1.025,95%CI:1.008-1.043,P=0.005).Conclusion:Treatment with esmolol were useful to reduced the reperfusion arrhythmia and play an important role in protective action,so the prognosis of AMI were improved.

关 键 词：艾司洛尔 再灌注心律失常 急性心肌梗死 再灌注治疗 受体阻滞剂 心室纤颤 住院期间 发生率 病死率 对照组 

分 类 号：R54[医药卫生—心血管疾病]