细胞钙离子转运蛋白参与高血压病程的相关研究  

The Relationship between Cell Calcium Transport Protein and Hypertension

作　　者：葛长江[1] 吕树铮[1] 胡申江[2] 季凤清[3] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心内科,北京100029 [2]浙江大学医学院附属第一医院心内科 [3]首都医科大学基础医学院组织胚胎教研室

出　　处：《心肺血管病杂志》2010年第S1期83-84,共2页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：Objective:To investigate the changes of calcium transport protein activities of aortic vascular smooth muscle cell in the progress of hypertension,evaluate the effects of irbesartan on them,then to elucidate the relationship between cell calcium transport protein and hypertension.Methods:Sixteen sixteen-week-old SHR were randomized into irbesartan treated group(IBT group,n=8)and distilled water group(DW group,n=8),and Wistar-Kyoto rats(WKY)as normal controls.Irbesartan and appropriate amounts of distilled water were administered respectively for 14 weeks by gavage.Blood pressure of caudal artery was examined before and after treatment,activities of Na+-K+-ATPase and Ca 2+-Mg 2+-ATPase of thoracic vascular aorta smooth muscle cell were measured.Results:Blood pressure in IBT group was much lower than that in DW group(129.17±3.71)vs(186.50±6.06),P<0.01).Compared with DW group,activities of Na+-K+-ATPase and Ca 2+-Mg 2+-ATPase of thoracic vascular aorta smooth muscle cell were remarkedly higher in both IBT group and WKY group(5.56±0.92)vs(2.91±0.56),P<0.01;(4.83±0.86)vs(2.76±0.43),P<0.01),(5.98±0.63)vs(2.91±0.56),P<0.01;(4.94±0.84)vs(2.76±0.43),P<0.01),while there was a slight difference between IBT group and WKY group(P>0.05).Activities of Na+-K+-ATPase and Ca 2-Mg 2+-ATPase of thoracic aorta smooth muscle cel were negatively relative to blood pressure(r=-0.446、r=-0.387,P<0.01).Conclusion:The changes of calcium transport protein activities of aortic vascular smooth muscle cell play an important role in the development of hypertension.Irbesartan may effectively inhibit the progress of hypertension by elevating calcium transport protein activities of vascular smooth muscel cell.Objective:To investigate the changes of calcium transport protein activities of aortic vascular smooth muscle cell in the progress of hypertension,evaluate the effects of irbesartan on them,then to elucidate the relationship between cell calcium transport protein and hypertension.Methods:Sixteen sixteen-week-old SHR were randomized into irbesartan treated group(IBT group,n=8)and distilled water group(DW group,n=8),and Wistar-Kyoto rats(WKY)as normal controls.Irbesartan and appropriate amounts of distilled water were administered respectively for 14 weeks by gavage.Blood pressure of caudal artery was examined before and after treatment,activities of Na+-K+-ATPase and Ca 2+-Mg 2+-ATPase of thoracic vascular aorta smooth muscle cell were measured.Results:Blood pressure in IBT group was much lower than that in DW group(129.17±3.71)vs(186.50±6.06),P<0.01).Compared with DW group,activities of Na+-K+-ATPase and Ca 2+-Mg 2+-ATPase of thoracic vascular aorta smooth muscle cell were remarkedly higher in both IBT group and WKY group(5.56±0.92)vs(2.91±0.56),P<0.01;(4.83±0.86)vs(2.76±0.43),P<0.01),(5.98±0.63)vs(2.91±0.56),P<0.01;(4.94±0.84)vs(2.76±0.43),P<0.01),while there was a slight difference between IBT group and WKY group(P>0.05).Activities of Na+-K+-ATPase and Ca 2-Mg 2+-ATPase of thoracic aorta smooth muscle cel were negatively relative to blood pressure(r=-0.446、r=-0.387,P<0.01).Conclusion:The changes of calcium transport protein activities of aortic vascular smooth muscle cell play an important role in the development of hypertension.Irbesartan may effectively inhibit the progress of hypertension by elevating calcium transport protein activities of vascular smooth muscel cell.

关 键 词：细胞钙离子 转运蛋白 自发性高血压大鼠 伊贝沙坦 相关研究 酶活性 主动脉平滑肌细胞 大鼠尾动脉 活性改变 蒸馏水 

分 类 号：R54[医药卫生—心血管疾病]