Modeling columnar spatiotemporal dynamics of nitric oxide as a primary controlling element of arteriole dilation during neurovascular coupling  

作　　者：YANG Yong WANG MingLai FAN YingLe ZHENG XiaoXiang 

机构地区：[1]Department of Biomedical Engineering,Hangzhou Dianzi University,Hangzhou 310018,China [2]College of Biomedical Engineering and Instruments,Zhejiang University,Hangzhou 310028,China

出　　处：《Science China(Life Sciences)》2010年第12期1418-1427,共10页中国科学(生命科学英文版)

基　　金：supported by the National Natural Science Foundation of China (Grant No. 30770685)

摘　　要：Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.

关 键 词：nitric oxide spatiotemporal dynamics cortex column neurovascular coupling arteriole dilation 

分 类 号：Q42[生物学—神经生物学]