Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution  

作　　者：IRWIN M. David 

机构地区：[1]Departments of Laboratory Medicine and Pathobiology and the Banting and Best Diabetes Centre, University of Toronto

出　　处：《Science China(Life Sciences)》2010年第6期677-682,共6页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China (Grant No. 2007CB411600);the National Natural Science Foundation of China (Grant Nos. 30621092 and 30623007);Bureau of Science and Technology of Yunnan Province

摘　　要：Motilin and ghrelin,members of a structure-function-related hormone family,play important roles in gastrointestinal function,regulation of energy homeostasis and growth hormone secretion.We observed episodic evolution in both of their prehormone gene sequences during primitive placental mammal evolution,during which most of the nonsynonymous changes result in radical substitution.Of note,a functional obestatin hormone might have only originated after this episodic evolution event.Early in placental mammal evolution,a series of biology complexities evolved.At the same time the motilin and ghrelin prehormone genes,which play important roles in several of these processes,experienced episodic evolution with dramatic changes in their coding sequences.These observations suggest that some of the lineage-specific physiological adaptations are due to episodic evolution of the motilin and ghrelin genes.Motilin and ghrelin,members of a structure-function-related hormone family,play important roles in gastrointestinal function,regulation of energy homeostasis and growth hormone secretion.We observed episodic evolution in both of their prehormone gene sequences during primitive placental mammal evolution,during which most of the nonsynonymous changes result in radical substitution.Of note,a functional obestatin hormone might have only originated after this episodic evolution event.Early in placental mammal evolution,a series of biology complexities evolved.At the same time the motilin and ghrelin prehormone genes,which play important roles in several of these processes,experienced episodic evolution with dramatic changes in their coding sequences.These observations suggest that some of the lineage-specific physiological adaptations are due to episodic evolution of the motilin and ghrelin genes.

关 键 词：MOTILIN ghrelin EPISODIC EVOLUTION 

分 类 号：Q951[生物学—动物学]