Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma  

作　　者：WANG GuiLan LU JiRong 

机构地区：[1]Department of Pediatrics,Zhongshan Boai Hospital,Zhongshan 528403,China [2]Department of Pediatrics,First Hospital,Jilin University,Changchun 130021,China

出　　处：《Science China(Life Sciences)》2010年第10期1215-1220,共6页中国科学(生命科学英文版)

摘　　要：This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.

关 键 词：asthma model retrovirus vector IL-4RA gene transfer 

分 类 号：R562.25[医药卫生—呼吸系统]