Polymer-assisted nanoparticulate contrast-enhancing materials  

作　　者：DING Yin1,3,HU Yong2,WU Wei1 & JIANG XiQun1 1Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering,College of Chemistry & Chemical Engineering,Nanjing University,Nanjing 210093,China 2National Laboratory of Solid State Microstructure,Department of Material Science and Engineering,Nanjing University,Nanjing 210093,China 3Key Laboratory of Analytical Chemistry for Life Science,Ministry of Education,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210093,China 

出　　处：《Science China Chemistry》2010年第3期479-486,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos 50625311,20874042)

摘　　要：The application of nanotechnology in medicine research has significant potential in modern biomedical research,disease diagnosis and therapy.Organic fluorophore-based detection techniques have been widely used as imaging and signal transduction tools for the detection of trace levels of analytes.The photosensitivity of the fluorophores,however,limits their application in such complex environments as living bio-systems where degradation or photobleaching occurs.Inorganic nanoparticles have unique and stable optical,electrical,magnetic and catalytic properties because of their various shapes,sizes and compositions.The potential of the nanoparticles as novel imaging agents has been studied as a possible solution to this problem.Surface modification of inorganic nanoparticles could enhance their biostability in physiological conditions and ability of targeting bioactive molecules.The application of nanotechnology in medicine research has significant potential in modern biomedical research,disease diagnosis and therapy.Organic fluorophore-based detection techniques have been widely used as imaging and signal transduction tools for the detection of trace levels of analytes.The photosensitivity of the fluorophores,however,limits their application in such complex environments as living bio-systems where degradation or photobleaching occurs.Inorganic nanoparticles have unique and stable optical,electrical,magnetic and catalytic properties because of their various shapes,sizes and compositions.The potential of the nanoparticles as novel imaging agents has been studied as a possible solution to this problem.Surface modification of inorganic nanoparticles could enhance their biostability in physiological conditions and ability of targeting bioactive molecules.

关 键 词：CONTRAST agent cell image GOLD NANOPARTICLES iron OXIDE NANOPARTICLES carbon NANOTUBES polymeric-inorganic hybrid NANOPARTICLES 

分 类 号：TB383.1[一般工业技术—材料科学与工程]