Alkoxy substituted MeO-BIPHEP-type diphosphines ligands for asymmetric hydrogenation of aryl ketones  

作　　者：Meng Lin Ma Zong Hai Peng Yu Guo Li Chen Hua Chen Xian Jun Li 

机构地区：[1]Department of Chemistry,Xihua University,Chengdu 610039,China [2]Key Lab of Green Chemistry and Technology,Ministry of Education,The Institute of Homogeneous Catalysis,Faculty of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Chinese Chemical Letters》2010年第5期576-579,共4页中国化学快报(英文版)

基　　金：the NSFC(No.20272037),the Doctor's Foundation of Education Ministry of China(No.20030610022);Foundation of Xihua University(No.R0723315) and(No.07ZA109) for the financial support of this work.

摘　　要：In this paper,a series of optically active MeO-BIPHEP-type ligands,（S）-6,6′-dimethoxy-2,2’-bis（di-p-alkoxyphenylphosphine）- 1,1′-biphenyl were synthesized and used to prepare the ruthenium complex.The effects of para-substituted were observed,the results showed that the ruthenium catalysts[diphosphine RuCl;diamine]containing both t-Bu and i-Pr substitutions have better activities and enantioselectivities than the non-substituted ruthenium catalysts in the asymmetric hydrogenation of acetophenone.In this paper,a series of optically active MeO-BIPHEP-type ligands,(S)-6,6′-dimethoxy-2,2’-bis(di-p-alkoxyphenylphosphine)- 1,1′-biphenyl were synthesized and used to prepare the ruthenium complex.The effects of para-substituted were observed,the results showed that the ruthenium catalysts[diphosphine RuCl₂ diamine]containing both t-Bu and i-Pr substitutions have better activities and enantioselectivities than the non-substituted ruthenium catalysts in the asymmetric hydrogenation of acetophenone.

关 键 词：Aryl ketone Asymmetric hydrogenation Biaryl phosphines ligands Ruthenium complex 

分 类 号：O621.13[理学—有机化学]