Blood Compatibility of Nano-Hydroxyapatite Dispersed Using Various Agents  

作　　者：YANG Lijian1, JIN Huafang2, YUAN Lin2 1. Hospital, Wuhan University of Technology, Wuhan 430070, Hubei, China 2. Biology Center,Wuhan University of Technology, Wuhan 430070, Hubei, China 

出　　处：《Wuhan University Journal of Natural Sciences》2010年第4期350-354,共5页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Basic Research Program of China(973 Program) (2005CB623905)

摘　　要：Nano-hydroxyapatite (nHAP),dispersed with three kinds of dispersants (heparin sodium,polyacrylic sodium and wa-ter),reacted with red blood cell,Bel-7402 tumor cell,to compare their dispersing efficiency against nHAP from one another. The blood compatibility of nHAP is also determined by blood solubil-ity experiment so that the capability of different dispersant dis-persing against nHAP of different concentration and the relation between nHAP and blood compatibility have been determined. The inhibiting function of Bel-7402 against tumor cells is deter-mined with the MTT staining method. The study result shows that heparin sodium has the best dispersing efficiency for nHAP with-out the phenomenon of hemolysis.Nano-hydroxyapatite (nHAP),dispersed with three kinds of dispersants (heparin sodium,polyacrylic sodium and wa-ter),reacted with red blood cell,Bel-7402 tumor cell,to compare their dispersing efficiency against nHAP from one another. The blood compatibility of nHAP is also determined by blood solubil-ity experiment so that the capability of different dispersant dis-persing against nHAP of different concentration and the relation between nHAP and blood compatibility have been determined. The inhibiting function of Bel-7402 against tumor cells is deter-mined with the MTT staining method. The study result shows that heparin sodium has the best dispersing efficiency for nHAP with-out the phenomenon of hemolysis.

关 键 词：NANO-HYDROXYAPATITE heparin sodium polyacrylic sodium blood compatibility 

分 类 号：N[自然科学总论]