Exposure to persistent organic pollutants as potential risk factors for developing diabetes  

作　　者：WANG ChunXiang,XU ShunQing,LV ZiQuan,LI YuanYuan,WANG YouJie & CHEN Tian Key Laboratory of Environment and Health,Ministry of Education School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China 

出　　处：《Science China Chemistry》2010年第5期980-994,共15页中国科学（化学英文版）

基　　金：support from the National Program on Key Basic Research Project(2008CB418206);National R&D Special Fund for Public Welfare Industry(200709052);Key Projects in the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period(2007BAC16B07);National Natural Science Foundation of China(20677018);Program for New Century Excellent Talents in University(NCET-04-0697)

摘　　要：Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.

关 键 词：persistent organic pollutants DIABETES DIOXINS POLYCHLORINATED BIPHENYLS ORGANOCHLORINE pesticides 

分 类 号：X503.1[环境科学与工程—环境工程]