L-Proline catalyzed aldol reactions between acetone and aldehydes in supercritical fluids:An environmentally friendly reaction procedure  

作　　者：LIU Ling LIU Zhao-Tie LIU Zhong-Wen XUE Dong 

机构地区：[1]Key Laboratory of Applied Surface and Colloid Chemistry(Shaanxi Normal University),Ministry of Education,Xi’an 710062,China [2]School of Chemistry&Materials Science,Shaanxi Normal University,Xi’an 710062,China

出　　处：《Science China Chemistry》2010年第7期1586-1591,共6页中国科学(化学英文版)

基　　金：the National Natural Science Foundation of China (20976102);Specialized Research Fund for the Doctoral Program of Higher Education (20070718003)

摘　　要：The direct asymmetric aldol reaction between various aldehydes and acetone catalyzed by L-proline catalyst was successfully carried out in supercritical CO_(2) (scCO_(2)) and 1,1,1,2-tetrafluoroethane (R-134a) fluids.The enantioselectivity of 84% ee to the targeted product was achieved under 20 MPa,40 °C,and 15 mol% of the catalyst in supercritical CO_(2) (scCO_(2)) fluid.The effects of reaction parameters,such as temperature,pressure,catalyst loading and different substituted aldehydes on both enantioselectivity and aldol yield were discussed.The titled reaction was also performed in 1,1,1,2-tetrafluoroethane,and the obtained results were compared with those in scCO2.This new reaction procedure provides an environmental asymmetric aldol reaction system as compared with that in organic solvents.The direct asymmetric aldol reaction between various aldehydes and acetone catalyzed by L-proline catalyst was successfully carried out in supercritical CO2 (scCO2) and 1,1,1,2-tetrafluoroethane (R-134a) fluids.The enantioselectivity of 84% ee to the targeted product was achieved under 20 MPa,40 °C,and 15 mol% of the catalyst in supercritical CO2 (scCO2) fluid.The effects of reaction parameters,such as temperature,pressure,catalyst loading and different substituted aldehydes on both enantioselectivity and aldol yield were discussed.The titled reaction was also performed in 1,1,1,2-tetrafluoroethane,and the obtained results were compared with those in scCO2.This new reaction procedure provides an environmental asymmetric aldol reaction system as compared with that in organic solvents.

关 键 词：L-PROLINE asymmetric aldol reaction supercritical CO_(2) 1 2-tetrafluoroethane fluid 

分 类 号：O643.32[理学—物理化学]