PEG-related polymer resins as synthetic supports  

作　　者：WANG Zheng1,YANG RuLei1,ZHU JunDong & ZHU XiaoXia2 1School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China 2Département de chimie,Université de Montréal,Montréal,QC H3C 3J7,Canada 

出　　处：《Science China Chemistry》2010年第9期1844-1852,共9页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (20674055);the Canada Research Chair Program

摘　　要：Combinatorial chemistry has become a significant part of the discovery and optimization process for novel drugs,affinity ligands,and catalysts.The polymeric supports play a key role in combinatory chemistry.Therefore,various kinds of functional polymer resins have been exploited as supports,reagents,and catalysts in organic synthesis.In comparison to the conventional Merrifield resins,the poly(ethylene glycol)(PEG)-related polymer resins have advantages including good compatibilities with polar solvents,good solvent absorbency and swelling properties.This review focuses primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis.Combinatorial chemistry has become a significant part of the discovery and optimization process for novel drugs,affinity ligands,and catalysts.The polymeric supports play a key role in combinatory chemistry.Therefore,various kinds of functional polymer resins have been exploited as supports,reagents,and catalysts in organic synthesis.In comparison to the conventional Merrifield resins,the poly(ethylene glycol)(PEG)-related polymer resins have advantages including good compatibilities with polar solvents,good solvent absorbency and swelling properties.This review focuses primarily on the more recent work in the field of developing PEG-related polymer resins as supports for organic synthesis.

关 键 词：combinatorial CHEMISTRY POLYMER RESINS poly(ethylene glycol) organic synthesis 

分 类 号：O633.1[理学—高分子化学]