分子诊断技术在耐多药结核分枝杆菌检测中的应用进展  

Molecular diagnosis technology on the multi-drug resistance mycobacterium tuberculosis

作　　者：张太松[1] 李明[1,2] 

机构地区：[1]中山大学达安基因诊断中心,广东广州510665 [2]南方医科大学生物技术学院,广东广州510515

出　　处：《分子诊断与治疗杂志》2009年第2期129-134,共6页Journal of Molecular Diagnostics and Therapy

摘　　要：在过去的十年间,多种分子诊断方法应用于耐多药结核分枝杆菌的检测,包括微阵列法、直接测序法、电泳或者杂交的方法等。本文拟对这些方法的优缺点、检测靶标基因与传统检测方法之间的比较及未来临床应用前景作简要综述。During the past decade, several molecular diagnostic methods have been developed to detect the multi-drug resistance mycobacterium tuberculosis, including microarray, direct sequencing, electrophoresis or hybridization. This article aims to review the advantages and disadvantages of these diagnostic methods, the target genes involved in these assays and the comparison between molecular methods and traditional diagnosis, as well as the prospects for clinical application in the later years.

关 键 词：结核分枝杆菌 分子诊断 耐药 

分 类 号：R450[医药卫生—治疗学]