β-TCP/HAP多孔生物陶瓷的制备  

Preparation of β-TCP/HAP Biphasic Porous Bioceramic

作　　者：郭朝邦[1] 金海波[1] 李广龙[1] 杨筠[2] 杜明奎[3] 毛克亚[3] 

机构地区：[1]北京理工大学材料科学与工程学院,北京100081 [2]中国科学院理化技术研究所,北京100190 [3]中国人民解放军总医院骨科,北京100853

出　　处：《人工晶体学报》2009年第S1期263-266,共4页Journal of Synthetic Crystals

基　　金：国家自然科学基金(No.50772132)

摘　　要：以牛松质骨为原料,采用低温煅烧工艺,通过调整浸泡溶液浓度及煅烧温度等工艺参数,制备出具有良好生物活性,并保持天然骨多孔结构的β-TCP/HAP双相生物陶瓷。并采用XRD,SEM等手段对其成分、微观结构进行表征。结果表明:所制备的β-TCP/HAP多孔生物陶瓷的大孔孔径在300~500μm之间,微孔孔径在1~5μm之间,具有良好的生物活性和生物可降解性。通过控制煅烧温度和浸泡溶液浓度,制备出含较高TCP的β-TCP/HAP多孔生物陶瓷,而煅烧温度或浸泡溶液浓度过高会导致制备的样品中TCP的含量降低,焦磷酸钙的含量增加。β-TCP/HAP biphasic bioceramic with good bioactivity and natural porous bone structure was fabricated by heating calcined bovine cancellouse bone with different quantities of NH4H2PO4 and sintered temperature.The crystalline phases and microstructure of specimens were determined by the XRD scanning electron microscope(SEM).The results revealed that the obtained β-TCP/HAP biphasic porous bioceramic with dimensions of 200~800 μm macropores and 1~5 μm micropores exhibited good biological activity and biodegradability.With NH4H2PO4 increasing in the calcined bovine bone,HAP would gradually convert into different crystalline phase compositions of TCP/HAP,TCP/HAP/Ca2P2O7 at high temperature.Similarly,raising the heating temperature,TCP would also gradually convert into Ca2P2O7.These results suggest that use different quantities of NH4H2PO4 as addition could improve the repeatability,precision and creditability of the study.

关 键 词：低温煅烧 双相钙磷陶瓷 多孔陶瓷 生物活性 

分 类 号：R318.08[医药卫生—生物医学工程]